Peregrin Antibody (2093C5a): sc-81059

Peregrin Antibody (2093C5a) is a mouse monoclonal IgG1 antibody that detects Peregrin protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Peregrin antibody (2093C5a) is available as a non-conjugated format. Peregrin protein, also known as BRPF1 or BR140, is a 1214 amino acid bromodomain and PHD finger-containing protein that plays a crucial role in gene regulation. Peregrin (2093C5a) antibody recognizes a protein primarily localized in the nucleus and expressed ubiquitously, with highest levels found in testis and spermatogonia. As a zinc-finger protein, Peregrin functions as a transcriptional activator, facilitating expression of target genes. Peregrin′s structure includes a C-terminal PWWP domain, which indicates potential DNA-binding activity, and similarity to transcriptional coactivators such as TAF II p250 further supports this role. Notably, Peregrin gene has been implicated in myeloid leukemia, suggesting disruptions in function may contribute to carcinogenesis. Alternative splicing of Peregrin gene results in production of two isoforms, which may have distinct regulatory functions.

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Peregrin Antibody (2093C5a) References:

1. The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene.  |  McCullagh, P., et al. 1999. Oncogene. 18: 7442-52. PMID: 10602503
2. The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans.  |  Chamberlin, HM. and Thomas, JH. 2000. Development. 127: 713-23. PMID: 10648230
3. The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?  |  Stec, I., et al. 2000. FEBS Lett. 473: 1-5. PMID: 10802047
4. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia.  |  Chaplin, T., et al. 1995. Blood. 85: 1435-41. PMID: 7888665
5. BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID.  |  Thompson, KA., et al. 1994. Biochem Biophys Res Commun. 198: 1143-52. PMID: 7906940
6. Gene BR140, which is related to AF10 and AF17, maps to chromosome band 3p25.  |  Gregorini, A., et al. 1996. Genes Chromosomes Cancer. 17: 269-72. PMID: 8946209

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Peregrin Antibody (2093C5a) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Peregrin Antibody (2093C5a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Peregrin Antibody (2093C5a) Specifications

Alternate Product Name: Peregrin

Product Clone Name: 2093C5a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Peregrin

Epitope Species: human

Product Reactivity/Detection: Peregrin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Peregrin Antibody (2093C5a): N/A