Molecular structure of Perazine Dihydrochloride, CAS Number: 5317-37-3
Perazine Dihydrochloride (CAS 5317-37-3)
Alternate Names:
10-[3-(4-Methyl-1-piperazinyl)propyl]-10H-phenothiazine Dihydrochloride
Application:
Perazine Dihydrochloride is a human cytochrome P450 isoenzyme 1A2 (CYP1A2) inhibitor
CAS Number:
5317-37-3
Molecular Weight:
412.42
Molecular Formula:
C20H25N3S•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Perazine is a human cytochrome P450 isoenzyme 1A2 (CYP1A2) inhibitor. Dixon analysis in human liver microsomes and Supersomes CYP1A2 showed potent inhibition of caffeine 3-N-demethylation and 1-N-demethylation, as well as moderate inhibition of caffeine 7-N-demethylation. Attenuation of C-8-hydroxylation was seen in Supersomes CYP1A2, however, weak inhibition of caffeine C-8-hydroxylation was found.
Perazine Dihydrochloride (CAS 5317-37-3) References
- Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. | Störmer, E., et al. 2000. Psychopharmacology (Berl). 151: 312-20. PMID: 11026737
- Different effects of amitriptyline and imipramine on the pharmacokinetics and metabolism of perazine in rats. | Daniel, WA., et al. 2000. J Pharm Pharmacol. 52: 1473-81. PMID: 11197075
- The effect of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics and metabolism of perazine in the rat. | Daniel, WA., et al. 2001. J Pharm Pharmacol. 53: 449-61. PMID: 11341361
- Examination of iron (III) and hexacyanoferrate (III) ions as reagents for the spectrophotometric determination of promazine and perazine. | Misiuk, W., et al. 2001. Acta Pol Pharm. 58: 421-5. PMID: 12197613
- Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4. | Wójcikowski, J., et al. 2002. Pol J Pharmacol. 54: 407-10. PMID: 12523495
- In-vitro immunomodulatory effects of haloperidol and perazine in schizophrenia. | Kowalski, J., et al. 2000. World J Biol Psychiatry. 1: 190-6. PMID: 12607215
- Effects of cytochrome P-450 inducers on the perazine metabolism in a primary culture of human hepatocytes. | Wójcikowski, J., et al. 2003. Pol J Pharmacol. 55: 655-8. PMID: 14581727
- The effect of the process variables on the HPLC separation of tricyclic neuroleptics on a calixarene-bonded stationary phase. | Hashem, H. and Jira, TH. 2005. Pharmazie. 60: 186-92. PMID: 15801670
- Effect of chronic treatment with perazine on lipopolysaccharide-induced interleukin-1 beta levels in the rat brain. | Obuchowicz, E., et al. 2006. Naunyn Schmiedebergs Arch Pharmacol. 373: 79-84. PMID: 16583240
- Perazine and carbamazepine in comparison to olanzapine in schizophrenia. | Ohlmeier, MD., et al. 2007. Neuropsychobiology. 55: 81-8. PMID: 17570951
- Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism--an in vitro study. | Wójcikowski, J. and Daniel, WA. 2009. Pharmacol Rep. 61: 851-8. PMID: 19904008
- Cytochrome P450-mediated interaction between perazine and risperidone: implications for antipsychotic polypharmacy. | Paulzen, M., et al. 2017. Br J Clin Pharmacol. 83: 1668-1675. PMID: 28160505
- Drug-Associated Liver Injury Related to Antipsychotics: Exploratory Analysis of Pharmacovigilance Data. | Zeiss, R., et al. J Clin Psychopharmacol. 42: 440-444. PMID: 35730552
- Ionization constants and distribution coefficients of phenothiazines and calcium channel antagonists determined by a pH-metric method and correlation with calculated partition coefficients. | Franke, U., et al. 1999. J Pharm Sci. 88: 89-95. PMID: 9874707
Inhibitor of:
CYP1A2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Perazine Dihydrochloride, 10 mg | sc-212537 | 10 mg | $375.00 |