Peramivir-13C, 15N2 (CAS 330600-85-6 (unlabeled))

Peramivir-13C,15N2 is a stable isotope-labeled variant of peramivir, where specific carbon atoms are replaced by carbon-13 (13C) and nitrogen atoms by nitrogen-15 (15N). This isotopic labeling is commonly used in research to enhance the study of the compound′s metabolic pathways, pharmacokinetics, and pharmacodynamics using advanced analytical techniques like mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Peramivir is a potent inhibitor of influenza viral neuraminidase, an enzyme that plays a crucial role in the viral life cycle. Neuraminidase facilitates the release of new influenza virus particles from infected cells by cleaving sialic acid residues on the surface glycoproteins of host cells and viral envelopes. By inhibiting this enzyme, peramivir prevents the spread of the virus from cell to cell, effectively halting the progression of the viral infection. In scientific research, Peramivir-13C,15N2 is particularly useful for detailed studies on how the compound interacts with the neuraminidase enzyme. The incorporation of stable isotopes allows researchers to observe subtle changes in the enzyme-inhibitor complex, providing insights into the binding dynamics and the mechanism of action at a molecular level. This research helps in understanding how structural modifications influence the efficacy of neuraminidase inhibitors. Furthermore, Peramivir-13C,15N2 is used to investigate the pharmacokinetics of peramivir. The labeled isotopes provide distinct signatures that allow for the precise tracking of the compound through various biological systems, helping to determine how it is absorbed, metabolized, and excreted. This information is vital for exploring how peramivir behaves in different environments and for optimizing its delivery and effectiveness.