Molecular structure of Pepstatin A, CAS Number: 26305-03-3
Pepstatin A (CAS 26305-03-3)
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Alternate Names:
Pepstatin A also known as Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid; Iva-Val-Val-Sta-Ala-Sta; AHMHA; 3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid); Isoval-Val-Val-Sta-Ala-Sta; IHN
Application:
Pepstatin A is an inhibitor of HIV-1 and aspartic proteases and can be used in the study of protease mechanisms
CAS Number:
26305-03-3
Purity:
>90%
Molecular Weight:
685.89
Molecular Formula:
C34H63N5O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pepstatin A inhibits the aspartic proteases cathepsin D, pepsin, and renin. Additionally, Pepstatin A suppresses p53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Pepstatin A also efficiently inhibits HIV-1 protease and Fcgamma receptor induction by IFN-gamma. Pepstatin A is a bacterial-derived chemotactic pentapeptide which is irreversibly inhibits aspartic proteases. Pepstatin A is also used as a research tool in studies of protease mechanisms and biological functions.
Pepstatin A (CAS 26305-03-3) References
- Localization of pepstatin's inhibitory action during Fc-mediated antibody internalization: possible implications for antibody-mediated viral transmission. | Athanassakis, I., et al. 2000. Cell Immunol. 199: 81-8. PMID: 10698617
- Purification and partial characterization of Oenococcus oeni exoprotease. | Farías, ME. and Manca de Nadra, MC. 2000. FEMS Microbiol Lett. 185: 263-6. PMID: 10754258
- Ab initio molecular dynamics-based assignment of the protonation state of pepstatin A/HIV-1 protease cleavage site. | Piana, S., et al. 2001. J Am Chem Soc. 123: 8730-7. PMID: 11535077
- Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines. | Tian, G., et al. 2002. J Biol Chem. 277: 31499-505. PMID: 12072428
- Plasmodium falciparum: differential sensitivity in vitro to E-64 (cysteine protease inhibitor) and Pepstatin A (aspartyl protease inhibitor). | Bailly, E., et al. 1992. J Protozool. 39: 593-9. PMID: 1522541
- The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A. | Borelli, C., et al. 2007. Proteins. 68: 738-48. PMID: 17510964
- A novel cell penetrating aspartic protease inhibitor blocks processing and presentation of tetanus toxoid more efficiently than pepstatin A. | Zaidi, N., et al. 2007. Biochem Biophys Res Commun. 364: 243-9. PMID: 17937927
- Purification of HIV-1 wild-type protease and characterization of proteolytically inactive HIV-1 protease mutants by pepstatin A affinity chromatography. | Wondrak, EM., et al. 1991. FEBS Lett. 280: 347-50. PMID: 2013336
- Candida albicans possesses Sap7 as a pepstatin A-insensitive secreted aspartic protease. | Aoki, W., et al. 2012. PLoS One. 7: e32513. PMID: 22384266
- Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. | Seelmeier, S., et al. 1988. Proc Natl Acad Sci U S A. 85: 6612-6. PMID: 3045820
- Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells. | Rahmani, S., et al. 2019. Molecules. 24: PMID: 30658511
- Construction of Pepstatin A-Conjugated ultrasmall SPIONs for targeted positive MR imaging of epilepsy-overexpressed P-glycoprotein. | Du, C., et al. 2020. Biomaterials. 230: 119581. PMID: 31718885
- Pepstatin, a new pepsin inhibitor produced by Actinomycetes. | Umezawa, H., et al. 1970. J Antibiot (Tokyo). 23: 259-62. PMID: 4912600
- Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. | Deiss, LP., et al. 1996. EMBO J. 15: 3861-70. PMID: 8670891
- Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. | Wu, GS., et al. 1998. Oncogene. 16: 2177-83. PMID: 9619826
Inhibitor of:
cathepsin D, HIV-1 Protease, Pepsin, Protease, and Renin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pepstatin A, 5 mg | sc-45036 | 5 mg | $60.00 | |||
Pepstatin A, 25 mg | sc-45036A | 25 mg | $185.00 | |||
Pepstatin A, 500 mg | sc-45036B | 500 mg | $1632.00 |