Molecular structure of PEPA, CAS Number: 141286-78-4
PEPA (CAS 141286-78-4)
Alternate Names:
2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide
Application:
PEPA is an allosteric potentiator of AMPA desensitization
CAS Number:
141286-78-4
Purity:
98%
Molecular Weight:
402.44
Molecular Formula:
C16H16F2N2O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Allosteric potentiator of AMPA desensitization. Decreases rate of onset of desensitization and potentiates steady-state equilibrium currents induced by Glu with splic variant and subunit selectivity. Enhances post-ischemic memory impairment in rats post i.v. administration.
PEPA (CAS 141286-78-4) References
- Overexpression, purification and biochemical characterization of the wound-induced leucine aminopeptidase of tomato. | Gu, YQ., et al. 1999. Eur J Biochem. 263: 726-35. PMID: 10469136
- Kinetic analysis of enzyme reactions. II. The potassium activation and calcium inhibition of pyruvic phosphoferase. | KACHMAR, JF. and BOYER, PD. 1953. J Biol Chem. 200: 669-82. PMID: 13034826
- Analysis of secreted proteins during conidial germination of Aspergillus oryzae RIB40. | Zhu, LY., et al. 2004. Biosci Biotechnol Biochem. 68: 2607-12. PMID: 15618633
- Facilitation of extinction learning for contextual fear memory by PEPA: a potentiator of AMPA receptors. | Zushida, K., et al. 2007. J Neurosci. 27: 158-66. PMID: 17202483
- Kinetic study of the combined effect of high hydrostatic pressure and temperature on the activity of Lactobacillus delbrueckii ssp. bulgaricus aminopeptidases. | Katsaros, GI., et al. 2009. J Food Sci. 74: E219-25. PMID: 19646036
- Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. | Ahmed, AH., et al. 2010. Biochemistry. 49: 2843-50. PMID: 20199107
- Facilitating actions of an AMPA receptor potentiator upon extinction of contextually conditioned fear response in stressed mice. | Yamada, D., et al. 2011. Neurosci Lett. 488: 242-6. PMID: 21094221
- Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell. | LaLumiere, RT., et al. 2012. Eur J Neurosci. 35: 614-22. PMID: 22321070
- Activation of AMPA receptor in the infralimbic cortex facilitates extinction and attenuates the heroin-seeking behavior in rats. | Chen, W., et al. 2016. Neurosci Lett. 612: 126-131. PMID: 26639425
- xerB, an Escherichia coli gene required for plasmid ColE1 site-specific recombination, is identical to pepA, encoding aminopeptidase A, a protein with substantial similarity to bovine lens leucine aminopeptidase. | Stirling, CJ., et al. 1989. EMBO J. 8: 1623-7. PMID: 2670557
- PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence. | Hauser, AR., et al. 1998. Mol Microbiol. 27: 807-18. PMID: 9515706
Activator of:
GluR, and GluR-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PEPA, 10 mg | sc-204178 | 10 mg | $131.00 | |||
| US: Only available in the US | ||||||
PEPA, 50 mg | sc-204178A | 50 mg | $582.00 | |||
| US: Only available in the US | ||||||