Pentamidine isethionate (CAS 140-64-7)
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Pentamidine isethionate is a compound that functions as a DNA synthesis inhibitor. It exerts its mechanism of action by binding to the minor groove of DNA, leading to the disruption of DNA replication and transcription processes. Pentamidine Isethionate interferes with the function of topoisomerases. By inhibiting these enzymes, pentamidine isethionate disrupts the normal functioning of DNA, ultimately leading to the inhibition of cell growth and proliferation. Pentamidine Isethionate may have a specific affinity for AT-rich regions of DNA, where it forms stable complexes, preventing the proper functioning of DNA. Pentamidine isethionate plays a role in experimental applications by interfering with DNA synthesis and transcription processes, making it useful for studying the molecular mechanisms of DNA metabolism.
Pentamidine isethionate (CAS 140-64-7) References
- Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs. | Akpa, PO., et al. 2008. Vet Parasitol. 151: 139-49. PMID: 18155842
- Pentamidine isethionate reduces Ia expression and antigen presentation by Langerhans cells and inhibits the contact hypersensitivity reaction. | Blaylock, BL., et al. 1991. J Immunol. 147: 2116-21. PMID: 1833452
- Characterizing the effect of pentamidine isethionate on the immune system using mouse splenocytes as an experimental model. | Plaza, DF., et al. 2007. J Immunotoxicol. 4: 279-85. PMID: 18958738
- Effect of free versus liposomal-complexed pentamidine isethionate on biological characteristics of Acanthamoeba castellanii in vitro. | Siddiqui, R., et al. 2009. J Med Microbiol. 58: 327-330. PMID: 19208882
- Physical characterization of pentamidine isethionate during freeze-drying-relevance to development of stable lyophilized product. | Sundaramurthi, P., et al. 2012. J Pharm Sci. 101: 1732-43. PMID: 22271285
- Pentamidine isethionate-induced neutrophil dysfunction. | Arnott, MA., et al. 1988. Ann Trop Med Parasitol. 82: 627-9. PMID: 3076751
- The In Vitro Effects of Pentamidine Isethionate on Coagulation and Fibrinolysis. | Al-Horani, RA., et al. 2019. Molecules. 24: PMID: 31174390
- Rationally designed hyaluronic acid-based nano-complexes for pentamidine delivery. | Carton, F., et al. 2019. Int J Pharm. 568: 118526. PMID: 31323370
- Efficacy and safety of pentamidine isethionate for tegumentary and visceral human leishmaniasis: a systematic review. | Piccica, M., et al. 2021. J Travel Med. 28: PMID: 33890115
- In Vitro Activity of Pentamidine Isethionate against Trophozoite and Cyst of Acanthamoeba. | Behnia, M., et al. 2021. Iran J Parasitol. 16: 560-566. PMID: 35082884
- Effects of pentamidine isethionate on Saccharomyces cerevisiae. | Ludewig, G., et al. 1994. Antimicrob Agents Chemother. 38: 1123-8. PMID: 8067749
- In vitro amoebicidal activity of propamidine and pentamidine isethionate against Acanthamoeba species and toxicity to corneal tissues. | Alizadeh, H., et al. 1997. Cornea. 16: 94-100. PMID: 8985640
- Effect of charcoal hemoperfusion on clearance of pentamidine isethionate after accidental overdose. | Watts, RG., et al. 1997. J Toxicol Clin Toxicol. 35: 89-92. PMID: 9022658
- In vitro inhibition of platelet function and coagulation by pentamidine isethionate. | Kempin, SJ., et al. 1977. Antimicrob Agents Chemother. 12: 451-4. PMID: 921238
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pentamidine isethionate, 50 mg | sc-204176 | 50 mg | $73.00 |