Penicillin Antibody (Pen 9): sc-57966

Penicillin Antibody (Pen 9) is a mouse monoclonal IgG1 antibody that detects Penicillin protein through enzyme-linked immunosorbent assay (ELISA). Anti-Penicillin antibody (Pen 9) is available as a non-conjugated format. Penicillin, a member of the β-lactam antibiotics group, features a unique β-lactam ring structure crucial for antibacterial activity. This structure enables Penicillin to inhibit peptidoglycan layer synthesis in bacterial cell walls, making anti-Penicillin antibody (Pen 9) a potent bactericidal agent primarily against Gram-positive bacteria. Penicillin′s structure binds to Penicillin-binding proteins (PBPs), essential for bacterial cell wall integrity. Bacterial resistance mechanisms can compromise Penicillin′s efficacy through β-lactamase production that hydrolyzes the β-lactam ring and altered PBPs with reduced binding affinity. Understanding these interactions helps develop strategies to combat antibiotic resistance and ensure effective bacterial infection treatments. Penicillins should not be administered to patients with histories of hives or anaphylactic responses.

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Penicillin Antibody (Pen 9) References:

1. PENICILLIN G AND RELATED COMPOUNDS.  |  HIGH, RH. and HUANG, NN. 1963. Pediatr Clin North Am. 10: 745-64. PMID: 14145017
2. THE RELATION BETWEEN PENICILLIN STRUCTURE AND PENICILLINASE ACTIVITY.  |  DEPUE, RH., et al. 1964. Arch Biochem Biophys. 107: 374-81. PMID: 14234487
3. Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides.  |  Hamilton, A., et al. 2006. Infect Immun. 74: 6179-87. PMID: 17057092
4. Reduced ability of penicillin to eradicate ingested group A streptococci from epithelial cells: clinical and pathogenetic implications.  |  Kaplan, EL., et al. 2006. Clin Infect Dis. 43: 1398-406. PMID: 17083011
5. Importance of amino acid alterations and expression of penicillin-binding protein 5 to ampicillin resistance of Enterococcus faecium in Taiwan.  |  Hsieh, SE., et al. 2006. Int J Antimicrob Agents. 28: 514-9. PMID: 17113270
6. Antibiotic selection in the penicillin-allergic patient.  |  Cunha, BA. 2006. Med Clin North Am. 90: 1257-64. PMID: 17116446
7. Resistance to penicillin of Staphylococcus aureus isolates from cows with high somatic cell counts in organic and conventional dairy herds in Denmark.  |  Bennedsgaard, TW., et al. 2006. Acta Vet Scand. 48: 24. PMID: 17125515
8. A comparison of the performance of two penicillin reagent kits in the diagnosis of beta-lactam hypersensitivity.  |  Romano, A., et al. 2007. Allergy. 62: 53-8. PMID: 17156342
9. Exploring the chemistry of penicillin as a beta-lactamase-dependent prodrug.  |  Ruddle, CC. and Smyth, TP. 2007. Org Biomol Chem. 5: 160-8. PMID: 17164921
10. Skin test for diagnosis of penicillin allergy--current status.  |  Ressler, C. and Mendelson, LM. 1987. Ann Allergy. 59: 167-70. PMID: 2443043
11. Penicillin concentration in saliva and its influence on bacterial interference.  |  Grahn, E. and Holm, SE. 1987. Scand J Infect Dis. 19: 235-41. PMID: 3112934
12. Penicillin treatment of streptococcal pharynigitis.  |  Bass, JW. 1973. JAMA. 224: 1038. PMID: 4739925

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Penicillin Antibody (Pen 9) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Penicillin Antibody (Pen 9) Specifications

Alternate Product Name: Penicillin

Product Clone Name: Pen 9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Penicillin

Epitope Species:

Product Reactivity/Detection: the thiazolidin ring of penicillin

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Penicillin Antibody (Pen 9): N/A