Penetratin (CAS 214556-79-3)

Penetratin, a cell-penetrating peptide (CPP), is renowned for its ability to facilitate the intracellular delivery of various bioactive molecules, including proteins, peptides, nucleic acids, and nanoparticles, across the cell membrane. Its mechanism of action is primarily attributed to its unique amphipathic structure, characterized by a hydrophobic domain and cationic residues, which enable interaction with cellular membranes and subsequent internalization into cells through endocytic or direct translocation pathways. In research, penetratin has been widely employed as a valuable tool for studying cellular uptake mechanisms and for enhancing the intracellular delivery of agents and biomolecules. Researchers have explored modifications to the penetratin sequence to optimize its cellular uptake efficiency, cellular specificity, and cargo delivery capacity. Furthermore, penetratin-based delivery systems have been investigated for various applications in molecular biology, drug delivery, genetics, and nanomedicine. Its versatility and efficacy in mediating intracellular delivery make penetratin a promising candidate for advancing research in fields such as targeted drug delivery, gene editing, and regenerative medicine, offering new avenues for the development of innovative biomedical technologies.