Date published: 2026-4-5

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PEG 10000 (CAS 25322-68-3)

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Alternate Names:
Poly(ethylene glycol)
Application:
PEG 10000 is a compound used to modify therapeutic proteins and peptides to increase their solubility
CAS Number:
25322-68-3
Molecular Weight:
~10000
Molecular Formula:
H(OCH2CH2)nOH
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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PEG 10000 is a polymer of ethylene oxide. This specific compound has a MW average of 10,000. PEG 10000 is a compound used to modify therapeutic proteins and peptides to increase their solubility. It is often used as a polar stationary phase for Gas Chromatorgraphy. Commonly also used in mass spec experiments. It is also used to preserve objects that have been retrieved from the ocean.


PEG 10000 (CAS 25322-68-3) References

  1. Effect of drug solubility and different excipients on floating behaviour and release from glyceryl monooleate matrices.  |  Kumar M, K., et al. 2004. Int J Pharm. 272: 151-60. PMID: 15019078
  2. A hemolysin from the mushroom Pleurotus eryngii.  |  Ngai, PH. and Ng, TB. 2006. Appl Microbiol Biotechnol. 72: 1185-91. PMID: 16804695
  3. Solvent systems for countercurrent chromatography: an aqueous two phase liquid system based on a room temperature ionic liquid.  |  Ruiz-Angel, MJ., et al. 2007. J Chromatogr A. 1151: 65-73. PMID: 17166506
  4. A new and selective and sensitive nanogold-labeled immunoresoance scattering spectral assay for trace prealbumin.  |  Hou, M., et al. 2007. Talanta. 72: 463-7. PMID: 19071641
  5. Hydrothermal synthesis of Ni(12)P(5) hollow microspheres, characterization and photocatalytic degradation property.  |  Li, J., et al. 2009. J Colloid Interface Sci. 332: 231-6. PMID: 19144350
  6. Poly(ethylene glycol)-modified gold nanorods as a photothermal nanodevice for hyperthermia.  |  Niidome, T., et al. 2009. J Biomater Sci Polym Ed. 20: 1203-15. PMID: 19520008
  7. Biosolubilization of rock phosphate by three stress-tolerant fungal strains.  |  Xiao, C., et al. 2011. Appl Biochem Biotechnol. 165: 719-27. PMID: 21625871
  8. Bioinspired insights into silicic acid stabilization mechanisms: the dominant role of polyethylene glycol-induced hydrogen bonding.  |  Preari, M., et al. 2014. J Am Chem Soc. 136: 4236-44. PMID: 24564240
  9. Fused silica capillaries with two segments of different internal diameters and inner surface roughnesses prepared by etching with supercritical water and used for volume coupling electrophoresis.  |  Horká, M., et al. 2017. Electrophoresis. 38: 1260-1267. PMID: 28229522
  10. Fabrication of β-conglycinin-stabilized nanoemulsions via ultrasound process and influence of SDS and PEG 10000 co-emulsifiers on the physicochemical properties of nanoemulsions.  |  Jin, H., et al. 2018. Food Res Int. 106: 800-808. PMID: 29579989
  11. Evaluation of microneedles-assisted in situ depot forming poloxamer gels for sustained transdermal drug delivery.  |  Khan, S., et al. 2019. Drug Deliv Transl Res. 9: 764-782. PMID: 30675693
  12. PEG/Sodium Tripolyphosphate-Modified Chitosan/Activated Carbon Membrane for Rhodamine B Removal.  |  Yang, J., et al. 2021. ACS Omega. 6: 15885-15891. PMID: 34179632
  13. Development of the Binary and Ternary Atorvastatin Solid Dispersions: In Vitro and In Vivo Investigations.  |  Faraji, E., et al. 2021. Biomed Res Int. 2021: 6644630. PMID: 34527740
  14. Immobilization of α-amylase in ethylcellulose electrospun fibers using emulsion-electrospinning method.  |  Hosseini, A., et al. 2022. Carbohydr Polym. 278: 118919. PMID: 34973738
  15. Enhanced loading and activity retention of bioactive proteins in hydrogel delivery systems.  |  Gehrke, SH., et al. 1998. J Control Release. 55: 21-33. PMID: 9795005

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PEG 10000, 500 g

sc-362504
500 g
$79.00

PEG 10000, 1 kg

sc-362504B
1 kg
$124.00

PEG 10000, 2 kg

sc-362504A
2 kg
$209.00

Hello I would like to ask about concentration of that material to make it liquid form by water?

Asked by: Mzzz2022
Thank you for your question. This compound is soluble in organic solvents, and water (50 mg/ml) at 25° C (clear, colorless). It is very soluble in aromatic hydrocarbons. Slightly soluble in aliphatic hydrocarbons.
Answered by: Tech Support Europe
Date published: 2022-03-09

What is the average particle size in units of length? Is it under 10 µm?

Asked by: vlwaggss
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2022-03-02

I would like to get a copy of the CoA for your current lot of this material. What is your polydispersity index spec for this product?

Asked by: kach
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Here is a sample CoA; http://datasheets.scbt.com/coa/coa.php?sc=sc-362504A&lot=A1420 Unfortunately I do not have polydispersity index information.
Answered by: Tech Service
Date published: 2020-06-15

I would like to get a copy of the CoA for your current lot of this material. What is your molecular weight spec for this product?

Asked by: Laysan
You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the sample CoA of our most recent lot. MW is ~10000.
Answered by: Technical Support
Date published: 2019-05-25
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Rated 5 out of 5 by from Various publications cite the use of PEGVarious publications cite the use of PEG 10000 to modify therapeutic proteins and peptides to increase their solubility. It is often used as a polar stationary phase for gas chromatorgraphy and mass spectrometry experiments. -SCBT Publication Review
Date published: 2015-06-01
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PEG 10000 is rated 5.0 out of 5 by 1.
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