PE-1 Antibody (ETV3F4D10): sc-81084

PE-1 Antibody (ETV3F4D10) is a mouse monoclonal IgG1 antibody that detects PE-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-PE-1 antibody (ETV3F4D10) is available as non-conjugated format. PE-1 protein, also known as PU-Ets related-1 or ETV3 (ETS translocation variant 3), belongs to the ETS family of transcription factors, characterized by a highly conserved DNA binding domain. PE-1 functions primarily as a transcriptional repressor, playing a crucial role in regulating growth factor pathways that control cellular proliferation and differentiation. PE-1 shows ubiquitous expression and predominantly localizes in the nucleus, where interleukin-10 can induce PE-1 through the STAT3 signaling pathway, contributing to anti-inflammatory effects associated with IL-10. During terminal cell differentiation, PE-1 participates in growth arrest by specifically repressing target genes linked to Ras-dependent proliferation, with anti-proliferative effects significantly influenced by interaction with Gemin3. Two isoforms of PE-1 exist due to alternative splicing, which may have distinct functional roles in cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PE-1 Antibody (ETV3F4D10) References:

1. Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element.  |  Bidder, M., et al. 2000. Biochemistry. 39: 8917-28. PMID: 10913304
2. PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation.  |  Sawka-Verhelle, D., et al. 2004. J Biol Chem. 279: 17772-84. PMID: 14754893
3. Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.  |  Hester, KD., et al. 2007. Cell Cycle. 6: 1594-604. PMID: 17525531
4. Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.  |  El Kasmi, KC., et al. 2007. J Immunol. 179: 7215-9. PMID: 18025162
5. PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23.  |  Klemsz, M., et al. 1994. Genomics. 20: 291-4. PMID: 8020980
6. Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF).  |  de Castro, CM., et al. 1997. Genomics. 42: 227-35. PMID: 9192842