Molecular structure of PDM 2, CAS Number: 688348-25-6
PDM 2 (CAS 688348-25-6)
Alternate Names:
1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-benzene
Application:
PDM 2 is a potent aryl hydrocarbon receptor antagonist
CAS Number:
688348-25-6
Molecular Weight:
283.6
Molecular Formula:
C14H9Cl3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PDM 2 is an analog of resveratrol acting as a potent and selective Aryl Hydrocarbon Receptor (Ah Receptor, AhR) antagonist. The Ah Receptor is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar.
PDM 2 (CAS 688348-25-6) References
- Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. | Denison, MS. and Nagy, SR. 2003. Annu Rev Pharmacol Toxicol. 43: 309-34. PMID: 12540743
- Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. | de Medina, P., et al. 2005. J Med Chem. 48: 287-91. PMID: 15634023
- Chain-breaking activity of resveratrol and piceatannol in a linoleate micellar model. | Rhayem, Y., et al. 2008. Chem Phys Lipids. 155: 48-56. PMID: 18590713
- Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta. | Wakx, A., et al. 2018. Int J Mol Sci. 19: PMID: 30486367
- Resveratrol Analogs with Antioxidant Activity Inhibit Intestinal Epithelial Cancer Caco-2 Cell Growth by Modulating Arachidonic Acid Cascade. | Storniolo, CE. and Moreno, JJ. 2019. J Agric Food Chem. 67: 819-828. PMID: 30575383
Inhibitor of:
Aryl Hydrocarbon Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDM 2, 10 mg | sc-205428 | 10 mg | $53.00 | |||
PDM 2, 50 mg | sc-205428A | 50 mg | $315.00 |