Molecular structure of PDK1/Akt/Flt Dual Pathway Inhibitor, CAS Number: 331253-86-2
PDK1/Akt/Flt Dual Pathway Inhibitor (CAS 331253-86-2)
Alternate Names:
6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one & 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
Application:
PDK1/Akt/Flt Dual Pathway Inhibitor is a cell-permeable compound that selectively induces apoptosis
CAS Number:
331253-86-2
Molecular Weight:
224.18
Molecular Formula:
C10H4N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A cell-permeable compound that selectively induces apoptosis in AML (Acute Myelogenous Leukemia) with little effect on normal CD34+ AML progenitor cells. Directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser473 and Thr308. The dual inhibition nature against both PDK1/Akt and Flt3/PIM signaling pathways allows effective elimination of AML cells that are otherwise resistant to inhibitors that target only the PDK1/Akt pathway.
Inhibitor of:
Akt, PDK1, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDK1/Akt/Flt Dual Pathway Inhibitor, 5 mg | sc-222144 | 5 mg | $241.00 |