Molecular structure of PDGFR Tyrosine Kinase Inhibitor VI, SU6668, CAS Number: 210644-62-5
PDGFR Tyrosine Kinase Inhibitor VI, SU6668 (CAS 210644-62-5)
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Application:
PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a potent ATP-competitive inhibitor against tyrosine kinases
CAS Number:
210644-62-5
Purity:
>97%
Molecular Weight:
310.4
Molecular Formula:
C18H18N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRb, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).
Inhibitor of:
ARK-2, ARK-3, c-Kit, FGFR, Flg, Flk-1, PDGF-C, PDGFR-beta, Ser/Thr Protein Kinase, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDGFR Tyrosine Kinase Inhibitor VI, SU6668, 5 mg | sc-204175 | 5 mg | $79.00 |