PDGFR Tyrosine Kinase Inhibitor III (CAS 205254-94-0)
See product citations (6)
QUICK LINKS
PDGFR Tyrosine Kinase Inhibitor III is a selective compound used in research to study the platelet-derived growth factor receptor (PDGFR) and its associated cellular pathways. By specifically inhibiting the tyrosine kinase activity of PDGFR, this inhibitor is useful for investigating the role of PDGFR signaling in cell proliferation, migration, and differentiation. PDGFR Tyrosine Kinase Inhibitor III allows researchers to dissect the contributions of PDGFR-mediated signaling to pathological conditions where PDGFR activity is often dysregulated. Furthermore, research involving this inhibitor may provide insights into the development of resistance to PDGFR-targeted approaches and contribute to the design of more effective strategies for intervention.
PDGFR Tyrosine Kinase Inhibitor III (CAS 205254-94-0) References
- Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. | Matsuno, K., et al. 2002. J Med Chem. 45: 3057-66. PMID: 12086491
- Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. | Matsuno, K., et al. 2002. J Med Chem. 45: 4513-23. PMID: 12238930
- Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. | Matsuno, K., et al. 2003. Bioorg Med Chem Lett. 13: 3001-4. PMID: 12941321
- Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 3. Replacement of quinazoline moiety and improvement of metabolic polymorphism of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. | Matsuno, K., et al. 2003. J Med Chem. 46: 4910-25. PMID: 14584942
- Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration. | Missinato, MA., et al. 2018. Development. 145: PMID: 29444893
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDGFR Tyrosine Kinase Inhibitor III, 1 mg | sc-204173 | 1 mg | $169.00 |