PDE8A Antibody (1H6): sc-293342

PDE8A Antibody (1H6) is a mouse monoclonal IgG2a kappa light chain antibody that detects PDE8A protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PDE8A antibody (1H6) is available as a non-conjugated format. PDE8A plays a crucial role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP), a second messenger vital for various cellular processes, including signal transduction, cell proliferation, and differentiation. By hydrolyzing cAMP to 5′AMP, PDE8A helps maintain appropriate cAMP levels, which is essential for normal physiological functions and cellular responses. Dysregulation of PDE8A activity has been implicated in several diseases, including cardiovascular disorders and neurological conditions, making PDE8A a significant target for therapeutic intervention. PDE8A is expressed in a diverse range of human tissues, including testis, ovary, small intestine, and colon, highlighting PDE8A′s importance in both reproductive and digestive systems. Additionally, PDE8A shares a high degree of sequence identity with PDE8B, which is predominantly found in the thyroid gland, suggesting potential functional similarities and interactions between these two phosphodiesterases.

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PDE8A Antibody (1H6) References:

1. Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells.  |  Sadhu, K., et al. 1999. J Histochem Cytochem. 47: 895-906. PMID: 10375378
2. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase.  |  Hetman, JM., et al. 2000. Proc Natl Acad Sci U S A. 97: 472-6. PMID: 10618442
3. PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women.  |  Chen, C., et al. 2009. Mol Hum Reprod. 15: 459-69. PMID: 19482904
4. PDE8A runs interference to limit PKA inhibition of Raf-1.  |  Maurice, DH. 2013. Proc Natl Acad Sci U S A. 110: 6248-9. PMID: 23550163
5. Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer.  |  Li, Z., et al. 2018. Cancer Lett. 432: 237-250. PMID: 29709702
6. Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents.  |  Chimienti, F., et al. 2019. Transl Psychiatry. 9: 91. PMID: 30770787
7. AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.  |  Qasim, H., et al. 2024. Circ Res. 134: 1006-1022. PMID: 38506047
8. Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase.  |  Rosman, GJ., et al. 1997. Gene. 191: 89-95. PMID: 9210593
9. Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation.  |  Gantner, F., et al. 1998. Br J Pharmacol. 123: 1031-8. PMID: 9559883
10. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase.  |  Fisher, DA., et al. 1998. Biochem Biophys Res Commun. 246: 570-7. PMID: 9618252
11. Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase.  |  Hayashi, M., et al. 1998. Biochem Biophys Res Commun. 250: 751-6. PMID: 9784418
12. Partial characterization of the active site human platelet cAMP phosphodiesterase, PDE3A, by site-directed mutagenesis.  |  Cheung, PP., et al. 1998. Arch Biochem Biophys. 360: 99-104. PMID: 9826434