Molecular structure of PDDHV, CAS Number: 179469-40-0
PDDHV (CAS 179469-40-0)
See product citations (2)
Alternate Names:
Phorbol 12,13-didecanoate 20-homovanillate
Application:
PDDHV is a RTX-type phorboid vanilloid with capsaicin-like selectivity for VR1 but with 100 times the potency
CAS Number:
179469-40-0
Molecular Weight:
837.09
Molecular Formula:
C49H72O11
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PDDHV is a resiniferatoxin (RTX)-type phorboid vanilloid with capsaicin-like selectivity for VR1, shown to evoke Ca2+ uptake in rat dorsal root ganglion neurons with an EC50 = 70nM, while inhibiting RTX binding to said neurons with a much lower potency (Ki > 10,000 nM). The ability of PDDHV to elicit Ca2+ uptake at sub-micromolar concentrations, while having a much lower binding affinity to rat dorsal root ganglion membranes, represents more than 100 times capsaicin-like pharmacology. PDDHV provides a tool to explore this capsaicin-like, vanilloid pharmacology..
PDDHV (CAS 179469-40-0) References
- Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1. | Szallasi, A., et al. 1999. Br J Pharmacol. 128: 428-34. PMID: 10510454
- The TRPV4 channel: structure-function relationship and promiscuous gating behaviour. | Nilius, B., et al. 2003. Pflugers Arch. 446: 298-303. PMID: 12715179
- Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death. | Shoeib, AM., et al. 2022. Int J Mol Sci. 23: PMID: 35328467
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDDHV, 1 mg | sc-24016 | 1 mg | $120.00 |