Pdcd-7 Antibody (S-18): sc-101250

Pdcd-7 Antibody (S-18) is a mouse monoclonal IgG2a kappa light chain antibody that detects Pdcd-7 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Pdcd-7 antibody (S-18) is available as a non-conjugated format. Pdcd-7, also known as programmed cell death protein 7, is a crucial regulator of apoptosis, consisting of 485 amino acids and promoting cell death when overexpressed. Pdcd-7 plays a significant role in the immune system by modulating apoptotic pathways, which is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation. Human and mouse versions of Pdcd-7 exhibit 95% homology in overlapping regions, underscoring evolutionary conservation of function across species. Pdcd-7 expression is particularly relevant in immune responses, as induction occurs in stimulated B and T cell lines, suggesting involvement in negative regulation of immune activities. Pdcd-7 serves as a valuable target for research in immunology and cancer therapy, where understanding apoptosis mechanisms can lead to novel therapeutic strategies.

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Pdcd-7 Antibody (S-18) References:

1. Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells.  |  Park, EJ., et al. 1999. Nucleic Acids Res. 27: 1524-30. PMID: 10037816
2. Increased expression of apoptosis-linked gene 2 (ALG2) in the rat brain after temporary focal cerebral ischemia.  |  Li, W., et al. 2000. Neuroscience. 96: 161-8. PMID: 10683420
3. PD-L2 is a second ligand for PD-1 and inhibits T cell activation.  |  Latchman, Y., et al. 2001. Nat Immunol. 2: 261-8. PMID: 11224527
4. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.  |  Ishida, Y., et al. 1992. EMBO J. 11: 3887-95. PMID: 1396582
5. Alterations of DNA copy number and expression in genes involved in cell cycle regulation and apoptosis signal pathways in gamma-radiation-sensitive SX9 cells and -resistant SR-1 cells.  |  Koshikawa, T., et al. 2005. Radiat Res. 163: 374-83. PMID: 15799692
6. Coordination of intrinsic, extrinsic, and endoplasmic reticulum-mediated apoptosis by imatinib mesylate combined with arsenic trioxide in chronic myeloid leukemia.  |  Du, Y., et al. 2006. Blood. 107: 1582-90. PMID: 16249384
7. Deregulated stress system in non-obese diabetic lymphocyte.  |  Liu, Z. and Aune, TM. 2006. Genes Immun. 7: 352-8. PMID: 16691184
8. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.  |  Agata, Y., et al. 1996. Int Immunol. 8: 765-72. PMID: 8671665

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pdcd-7 Antibody (S-18) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Pdcd-7 Antibody (S-18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pdcd-7 Antibody (S-18) Specifications

Alternate Product Name: Pdcd-7

Product Clone Name: S-18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 47-146

Epitope Target: Pdcd-7

Epitope Species: human

Product Reactivity/Detection: Pdcd-7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Pdcd-7 Antibody (S-18): N/A