PDCD1LG2/PD-L2 Antibody (TY25): sc-57398
- PDCD1LG2/PD-L2 Antibody (TY25) is a rat monoclonal IgG2a PDCD1LG2/PD-L2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against PD-L2 transfected RAW264.7 cells of mouse origin
- PDCD1LG2/PD-L2 Antibody (TY25) is recommended for detection of PD-L2 of mouse origin by WB, IP, IF, IHC(P) and FCM
- Anti-PDCD1LG2/PD-L2 Antibody (TY25) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PDCD1LG2/PD-L2 (TY25): sc-57398.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PDCD1LG2/PD-L2 Antibody (TY25). This work is in progress.
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SEE ALSO...
Pdcd-1L2 Antibody (TY25) is a rat monoclonal IgG2a antibody that detects the Pdcd-1L2 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Pdcd-1L2 antibody (TY25) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Pdcd-1L2, also known as programmed cell death ligand-2, is a 73 amino acid type I transmembrane protein that plays a crucial role in the immune system by providing inhibitory signals to T cells, thereby regulating immune responses and maintaining tolerance. Pdcd-1L2′s structure includes a signal sequence, immunoglobulin V-like and C-like domains, a transmembrane region, and a cytoplasmic region, which are essential for mediating interactions with immune receptors. The gene encoding Pdcd-1L2 is located on human chromosome 9p24.2, and Pdcd-1L2 expression on various parenchymal cells, such as those in the heart, lung, and kidney, suggests that the Pdcd-1-Pdcd-L system may be pivotal in preventing autoimmune diseases by modulating T cell activity. Pdcd-1L2′s ability to interact with other proteins in the immune system further underscores its importance in maintaining immune homeostasis and preventing excessive immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PDCD1LG2/PD-L2 Antibody (TY25) References:
- B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. | Dong, H., et al. 1999. Nat Med. 5: 1365-9. PMID: 10581077
- Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. | Freeman, GJ., et al. 2000. J Exp Med. 192: 1027-34. PMID: 11015443
- PD-L2 is a second ligand for PD-1 and inhibits T cell activation. | Latchman, Y., et al. 2001. Nat Immunol. 2: 261-8. PMID: 11224527
- PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. | Nishimura, H. and Honjo, T. 2001. Trends Immunol. 22: 265-8. PMID: 11323285
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDCD1LG2/PD-L2 Antibody (TY25) | sc-57398 | 200 µg/ml | $316.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) AC | sc-57398 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) HRP | sc-57398 HRP | 200 µg/ml | $316.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) FITC | sc-57398 FITC | 200 µg/ml | $330.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) PE | sc-57398 PE | 200 µg/ml | $343.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) Alexa Fluor® 488 | sc-57398 AF488 | 200 µg/ml | $357.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) Alexa Fluor® 546 | sc-57398 AF546 | 200 µg/ml | $357.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) Alexa Fluor® 594 | sc-57398 AF594 | 200 µg/ml | $357.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) Alexa Fluor® 647 | sc-57398 AF647 | 200 µg/ml | $357.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) Alexa Fluor® 680 | sc-57398 AF680 | 200 µg/ml | $357.00 | |||
PDCD1LG2/PD-L2 Antibody (TY25) Alexa Fluor® 790 | sc-57398 AF790 | 200 µg/ml | $357.00 |