Date published: 2025-12-18

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PD 98059 (CAS 167869-21-8)

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Application:
PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1.
CAS Number:
167869-21-8
Purity:
≥98%
Molecular Weight:
267.28
Molecular Formula:
C16H13NO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1 (MAPKK1 or MAPKs) that binds to the inactive form of MEK-1, blocking MEK-1 activation and leading to inhibition of phosphorylation and the activation of MAP kinase. In PC12 pheochromocytoma cells, it produced complete blockage of any increase in MAPK activity (IC50 = 2 muM) produced by nerve growth factor. It may act to enhance self-renewal of embryonic stem cells and has been used to unravel the role of the MAPK cascade in biological systems. The compound has been reported to induce GSTA2 (glutathione S-transferase A2) production in H4IIE cells. PD 98059 has also been shown to enhance insulin-mediated increase in glutathione levels as well as, independent of MEK1 inhibition, elevate primary cultured rat hepatocyte glutathione levels.


PD 98059 (CAS 167869-21-8) References

  1. Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.  |  Badache, A. and Hynes, NE. 2001. Cancer Res. 61: 383-91. PMID: 11196191
  2. Activation of CCAAT/enhancer-binding protein beta by 2'-amino-3'-methoxyflavone (PD98059) leads to the induction of glutathione S-transferase A2.  |  Kang, KW., et al. 2003. Carcinogenesis. 24: 475-82. PMID: 12663507
  3. BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways.  |  Qi, X., et al. 2004. Proc Natl Acad Sci U S A. 101: 6027-32. PMID: 15075392
  4. Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes.  |  Kim, SK., et al. 2004. J Pharmacol Exp Ther. 311: 99-108. PMID: 15169830
  5. The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek.  |  Kim, SK., et al. 2006. Drug Metab Dispos. 34: 683-9. PMID: 16443668
  6. Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.  |  Kojima, K., et al. 2007. Cancer Res. 67: 3210-9. PMID: 17409429
  7. Estradiol postconditioning relieves ischemia/reperfusion injury in axial skin flaps of rats, inhibits apoptosis and alters the MKP-1/ERK pathway.  |  Jin, Q., et al. 2017. Mol Med Rep. 16: 1472-1478. PMID: 29067454
  8. Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation.  |  Gündüz, D., et al. 2019. Front Physiol. 10: 1387. PMID: 31787905
  9. D-allose alleviates ischemia/reperfusion (I/R) injury in skin flap via MKP-1.  |  Ju, J., et al. 2020. Mol Med. 26: 21. PMID: 32046628
  10. Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF-κB signaling pathway.  |  Zhang, Q., et al. 2022. Arch Biochem Biophys. 730: 109394. PMID: 36100082
  11. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.  |  Alessi, DR., et al. 1995. J Biol Chem. 270: 27489-94. PMID: 7499206
  12. A synthetic inhibitor of the mitogen-activated protein kinase cascade.  |  Dudley, DT., et al. 1995. Proc Natl Acad Sci U S A. 92: 7686-9. PMID: 7644477
  13. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.  |  Cuenda, A., et al. 1995. FEBS Lett. 364: 229-33. PMID: 7750577
  14. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor.  |  Pang, L., et al. 1995. J Biol Chem. 270: 13585-8. PMID: 7775407
  15. Effects of mitogen-activated protein kinase kinase inhibitor PD 098059 on antigen challenge of guinea-pig airways in vitro.  |  Tsang, F., et al. 1998. Br J Pharmacol. 125: 61-8. PMID: 9776345

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PD 98059, 1 mg

sc-3532
1 mg
$39.00

PD 98059, 5 mg

sc-3532A
5 mg
$90.00