Molecular structure of PD-85639, CAS Number: 150034-24-5
PD-85639 (CAS 150034-24-5)
Application:
PD-85639 is a potent and selective sodium channel blocker for anesthetic receptor
CAS Number:
150034-24-5
Molecular Weight:
364.5
Molecular Formula:
C24H32N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD-85639 is a potent and selective sodium channel blocker. It binds specifically to a local anesthetic receptor site on the Na+ channel α-subunit that is allosterically linked to neurotoxin receptor site 21. PD-85639 is a novel and useful molecular probe of this important drug receptor site.
PD-85639 (CAS 150034-24-5) References
- WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels. | Wanner, SG., et al. 1999. Biochemistry. 38: 11137-46. PMID: 10460170
- Medicinal chemistry of neuronal voltage-gated sodium channel blockers. | Anger, T., et al. 2001. J Med Chem. 44: 115-37. PMID: 11170622
- Design, synthesis and in vivo anticonvulsant screening in mice of novel phenylacetamides. | Shindikar, AV., et al. 2006. Eur J Med Chem. 41: 786-92. PMID: 16647165
- Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. | Roufos, I., et al. 1994. J Med Chem. 37: 268-74. PMID: 8295214
- Inhibition of Na+ channels by the novel blocker PD85,639. | Ragsdale, DS., et al. 1993. Mol Pharmacol. 43: 949-54. PMID: 8391119
- Specific binding of the novel Na+ channel blocker PD85,639 to the alpha subunit of rat brain Na+ channels. | Thomsen, W., et al. 1993. Mol Pharmacol. 43: 955-64. PMID: 8391120
- A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers. | Roufos, I., et al. 1996. J Med Chem. 39: 1514-20. PMID: 8691482
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD-85639, 5 mg | sc-201084 | 5 mg | $77.00 | |||
PD-85639, 25 mg | sc-201084A | 25 mg | $309.00 |