PD 174265 (CAS 216163-53-0)
See product citations (4)
QUICK LINKS
PD 174265 is a selective inhibitor used in biochemical research to target the epidermal growth factor receptor tyrosine kinase (EGFR TK). This compound is instrumental in studying the signal transduction pathways mediated by EGFR TK, which are for the regulation of cell proliferation, survival, and differentiation. By inhibiting EGFR TK, PD 174265 allows researchers to investigate the effects of EGFR blockade on cellular processes and to better understand the mechanisms underlying conditions characterized by aberrant EGFR signaling. The inhibitor is also useful in examining the dynamics of EGFR TK-related pathways in various cell types and contributes to the identification of molecular targets for potential interventions in diseases where EGFR plays a key role. Additionally, PD 174265 is applied in the study of resistance mechanisms that can arise with continuous EGFR inhibition.
PD 174265 (CAS 216163-53-0) References
- Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. | Gobert, RP., et al. 2009. Mol Cell Biol. 29: 1538-53. PMID: 19139271
- Chemical interrogation of the neuronal kinome using a primary cell-based screening assay. | Al-Ali, H., et al. 2013. ACS Chem Biol. 8: 1027-36. PMID: 23480631
- In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2. | Vancraenenbroeck, R., et al. 2014. Front Mol Neurosci. 7: 51. PMID: 24917786
- Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis. | Morel, M., et al. 2014. Int J Parasitol Drugs Drug Resist. 4: 256-66. PMID: 25516836
- The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules. | Simon, K., et al. 2016. J Biol Chem. 291: 705-18. PMID: 26620557
- The use of novel selectivity metrics in kinase research. | Bosc, N., et al. 2017. BMC Bioinformatics. 18: 17. PMID: 28056771
- Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation. | Schlüter, A., et al. 2018. Brain Pathol. 28: 902-919. PMID: 29476661
- Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides. | Wang, S., et al. 2018. Nucleic Acids Res. 46: 3579-3594. PMID: 29514240
- A kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media. | Noel, J., et al. 2020. PLoS One. 15: e0235634. PMID: 32760078
- Data-driven prioritization and preclinical evaluation of therapeutic targets in glioblastoma. | Brahm, CG., et al. 2020. Neurooncol Adv. 2: vdaa151. PMID: 33392504
- Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination. | Chunder, R., et al. 2022. Proc Natl Acad Sci U S A. 119: e2117034119. PMID: 35235454
- Bisphenol A Impairs Lipid Remodeling Accompanying Cell Differentiation in the Oligodendroglial Cell Line Oli-Neu. | Naffaa, V., et al. 2022. Molecules. 27: PMID: 35408676
- Epigenetic priming of immune/inflammatory pathways activation and abnormal activity of cell cycle pathway in a perinatal model of white matter injury. | Schang, AL., et al. 2022. Cell Death Dis. 13: 1038. PMID: 36513635
- Impact of the Voltage-Gated Calcium Channel Antagonist Nimodipine on the Development of Oligodendrocyte Precursor Cells. | Enders, M., et al. 2023. Int J Mol Sci. 24: PMID: 36835129
- Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. | Fry, DW., et al. 1998. Proc Natl Acad Sci U S A. 95: 12022-7. PMID: 9751783
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 174265, 1 mg | sc-204170 | 1 mg | $163.00 |