PD-173952 (CAS 305820-75-1)
Alternate Names:
6-(2,6-Dichlorophenyl)-8-methyl-2-[[4-(4-morpholinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one
CAS Number:
305820-75-1
Molecular Weight:
482.36
Molecular Formula:
C24H21Cl2N5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD-173952 is a potent and selective inhibitor of the tyrosine kinase activity of FAK (focal adhesion kinase). It functions by binding to the ATP-binding site of FAK, preventing its phosphorylation and subsequent activation. This inhibition disrupts the signaling pathways involved in cell migration, proliferation, and survival, ultimately leading to the suppression of tumor growth and metastasis. PD-173952 targets the autophosphorylation site of FAK, interfering with its interaction with other proteins and downstream signaling cascades. By blocking FAK activity, PD-173952 hinders the formation of focal adhesions and impairs the ability of cancer cells to invade surrounding tissues.
PD-173952 (CAS 305820-75-1) References
- Application of docking and QM/MM-GBSA rescoring to screen for novel Myt1 kinase inhibitors. | Wichapong, K., et al. 2014. J Chem Inf Model. 54: 881-93. PMID: 24490903
- Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies. | Moussaud, S., et al. 2015. Expert Opin Ther Targets. 19: 589-603. PMID: 25785645
- Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays. | Rohe, A., et al. 2015. Bioorg Med Chem. 23: 4936-4942. PMID: 26059593
- Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. | Platzer, C., et al. 2018. Bioorg Med Chem. 26: 4014-4024. PMID: 29941193
- Computer-aided design, synthesis and biological characterization of novel inhibitors for PKMYT1. | Najjar, A., et al. 2019. Eur J Med Chem. 161: 479-492. PMID: 30388464
- Overexpressed PKMYT1 promotes tumor progression and associates with poor survival in esophageal squamous cell carcinoma. | Zhang, Q., et al. 2019. Cancer Manag Res. 11: 7813-7824. PMID: 31695486
- Overexpression of PKMYT1 Facilitates Tumor Development and Is Correlated with Poor Prognosis in Clear Cell Renal Cell Carcinoma. | Chen, P., et al. 2020. Med Sci Monit. 26: e926755. PMID: 33024069
- Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein. | Yamamoto, M., et al. 2022. mBio. 13: e0051922. PMID: 35708281
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD-173952, 5 mg | sc-478278 | 5 mg | $119.00 | |||
PD-173952, 10 mg | sc-478278A | 10 mg | $275.00 | |||
PD-173952, 25 mg | sc-478278B | 25 mg | $612.00 | |||
PD-173952, 100 mg | sc-478278C | 100 mg | $1878.00 |