Molecular structure of PD 168368, CAS Number: 204066-82-0
PD 168368 (CAS 204066-82-0)
See product citations (3)
Alternate Names:
PD 168368 is known as an NMBR antagonist.
Application:
PD 168368 is a potent NMB (Neuromedin B) receptor antagonist that displays ~40-fold selectivity over the gastrin-releasing peptide receptor.
CAS Number:
204066-82-0
Purity:
≥96%
Molecular Weight:
554.65
Molecular Formula:
C31H34N6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD 168368 is a Neuromedin B antagonist displaying ~40-fold selectivity over the gastrin-releasing peptide receptor (GRP-R, BB2). PD 168368 also shows >300-fold selectivity over BRS-R (BB3). PD 168368 antagonizes neuromedin B-stimulated Ca2+ release. Simultaneously, PD 168368 inhibits proliferation of rat glioma cells.
PD 168368 (CAS 204066-82-0) References
- Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368. | Ryan, RR., et al. 1999. J Pharmacol Exp Ther. 290: 1202-11. PMID: 10454496
- Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368. | Tokita, K., et al. 2001. J Biol Chem. 276: 495-504. PMID: 11013243
- Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells. | Moody, TW., et al. 2000. Eur J Pharmacol. 409: 133-42. PMID: 11104826
- Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells. | Moody, TW., et al. 2003. Eur J Pharmacol. 474: 21-9. PMID: 12909192
- Isolation, identification and biological activity of gastrin-releasing peptide 1-46 (oGRP 1-46), the primary GRP gene-derived peptide product of the pregnant ovine endometrium. | Giraud, AS., et al. 2010. Peptides. 31: 284-90. PMID: 19944725
- Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. | Schepetkin, IA., et al. 2011. Mol Pharmacol. 79: 77-90. PMID: 20943772
- The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats. | Su, PY. and Ko, MC. 2011. J Pharmacol Exp Ther. 337: 822-9. PMID: 21421741
- Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo. | Park, HJ., et al. 2011. Cancer Lett. 312: 117-27. PMID: 21908103
- 3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2. | Schepetkin, IA., et al. 2013. Biochem Pharmacol. 85: 404-16. PMID: 23219934
- Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. | Sukhtankar, DD. and Ko, MC. 2013. PLoS One. 8: e67422. PMID: 23826298
- Neuromedin B receptor antagonism inhibits migration, invasion, and epithelial-mesenchymal transition of breast cancer cells. | Park, HJ., et al. 2016. Int J Oncol. 49: 934-42. PMID: 27571778
- Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons. | Ehling, S., et al. 2019. Acta Derm Venereol. 99: 587-893. PMID: 30734045
- Neuromedin B receptor disruption impairs adipogenesis in mice and 3T3-L1 cells. | de Paula, GSM., et al. 2019. J Mol Endocrinol. 63: 93-102. PMID: 31067509
Inhibitor of:
GRPR, and NMBR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 168368, 1 mg | sc-204166 | 1 mg | $149.00 | |||
PD 168368, 10 mg | sc-204166A | 10 mg | $312.00 |