PD 168368 CAS: 204066-82-0
MF: C31H34N6O4
MW: 554.65
A NMBR (Neuromedin B) antagonist.

PD 168368 (CAS 204066-82-0)

PD 168368 | CAS 204066-82-0 is rated 5.0 out of 5 by 1.
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Application: PD 168368 is a NMBR (Neuromedin B) antagonist
CAS Number: 204066-82-0
Purity: ≥96%
Molecular Weight: 554.65
Molecular Formula: C31H34N6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

PD 168368 is a NMBR (Neuromedin B) antagonist displaying ~40-fold selectivity over GRP-R, BB2 and >300-fold selectivity over BRS-R. Antagonizes neuromedin B-stimulated Ca2+ release and inhibits proliferation of rat glioma cells.


References

1. Ryan, R R., et al., 1999. Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368. The Journal of pharmacology and experimental therapeutics. 290(3): 1202-11. PMID: 10454496
2. Moody, T W., et al., 2000. Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells. European journal of pharmacology. 409(2): 133-42. PMID: 11104826
3. Moody, Terry W., et al., 2003. Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells. European journal of pharmacology. 474(1): 21-9. PMID: 12909192
4. Park, H.J. et al. 2011. Cancer Lett. 312(1): 117-127. PMID: 21908103

Usage :
It is recommend to use solutions containing sc-204166 within the same day they are made. To store a solution, aliquot into usable amounts and store at -20°C for up to two weeks.
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Boiling Point :
~819.7° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
Ki Data :
NMBR: Ki= 0.15 nM (human); GRPR: Ki= 17 nM (human)
pK Values :
pKa: 11.6 (Predicted), pKb: 5.65 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9937534
MDL Number :
MFCD09971100
SMILES :
C[[email protected]](CC1=CNC2=CC=CC=C21)(C(=O)NCC3(CCCCC3)C4=CC=CC=N4)NC(=O)NC5=CC=C(C=C5)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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PD 168368 (CAS 204066-82-0) Product Citations

See how others have used PD 168368 (CAS 204066-82-0). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26522854  Tsai, CC. et al. 2015. Scientific reports. 5: 15879.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Park Park, HJ. et al. (PubMed 21908103) reported that the Neuromedin B receptor antagonist, PD 168368, suppresses tumor angiogenesis and tumor growth in vitro and in vivo. -SCBT Publication Review
Date published: 2015-01-02
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