Molecular structure of PD 153035 Hydrochloride, CAS Number: 183322-45-4
PD 153035 Hydrochloride (CAS 183322-45-4)
Application:
PD 153035 Hydrochloride is a potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase
CAS Number:
183322-45-4
Purity:
≥99%
Molecular Weight:
396.67
Molecular Formula:
C16H14BrN3O2 HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 25 pM). Only inhibits other purified tyrosine kinases at micromolar or higher concentrations.
PD 153035 Hydrochloride (CAS 183322-45-4) References
- Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor. | Yucel-Lindberg, T., et al. 1999. Biochem Biophys Res Commun. 257: 528-32. PMID: 10198245
- Epidermal growth factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1beta. | Yucel-Lindberg, T. and Brunius, G. 2006. Arch Oral Biol. 51: 892-8. PMID: 16678783
- Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts. | Yucel-Lindberg, T., et al. 2006. Cell Signal. 18: 2131-42. PMID: 16766159
- Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression. | Surh, YJ. and Kundu, JK. 2007. Curr Cancer Drug Targets. 7: 447-58. PMID: 17691904
- Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. | Toh, B., et al. 2011. PLoS Biol. 9: e1001162. PMID: 21980263
- Irreversible EGFR inhibitor EKB-569 targets low-LET γ-radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma. | Aravindan, N., et al. 2011. PLoS One. 6: e29705. PMID: 22242139
- Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. | Taylor, DP., et al. 2014. Breast Cancer Res Treat. 144: 551-60. PMID: 24610032
- Absence of TGF-β Receptor Activation by Highly Purified hCG Preparations. | Koistinen, H., et al. 2015. Mol Endocrinol. 29: 1787-91. PMID: 26495869
- Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation. | Natarajan, K., et al. 2019. Am J Physiol Lung Cell Mol Physiol. 317: L127-L140. PMID: 31042082
- Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts. | Alim, MA., et al. 2021. Front Immunol. 12: 801096. PMID: 35087525
- A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. | Fry, DW., et al. 1994. Science. 265: 1093-5. PMID: 8066447
- Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. | Bridges, AJ., et al. 1996. J Med Chem. 39: 267-76. PMID: 8568816
- PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. | Bos, M., et al. 1997. Clin Cancer Res. 3: 2099-106. PMID: 9815602
Inhibitor of:
EGFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 153035 Hydrochloride, 10 mg | sc-205963 | 10 mg | $125.00 | |||
PD 153035 Hydrochloride, 50 mg | sc-205963A | 50 mg | $525.00 |