Molecular structure of PD 135158, CAS Number: 130325-35-8
PD 135158 (CAS 130325-35-8)
Alternate Names:
CAM 1028
Application:
PD 135158 is a selective CCK-BR antagonist used for research purposes
CAS Number:
130325-35-8
Molecular Weight:
616.76
Molecular Formula:
C35H44N4O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
PD 135158 is a specific and effective CCK-BR antagonist (cholecystokinin type B). CCK is a neuroendocrine peptide described to play an important role in cell growth, cell proliferation, and other biological functions. PD 135158 has been reported to show limited affinity for substance P, benzodiazepine, GABAA, neurotensin, bradykinin, and 5-HT3 binding sites.
PD 135158 (CAS 130325-35-8) References
- Anxiogenic effect of cholecystokinin in the dorsal periaqueductal gray. | Netto, CF. and Guimarães, FS. 2004. Neuropsychopharmacology. 29: 101-7. PMID: 14583742
- Devazepide, a nonpeptide antagonist of CCK receptors, induces apoptosis and inhibits Ewing tumor growth. | Carrillo, J., et al. 2009. Anticancer Drugs. 20: 527-33. PMID: 19407653
- Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. | Hughes, J., et al. 1990. Proc Natl Acad Sci U S A. 87: 6728-32. PMID: 1975695
- PD 135158, a CCKB/gastrin receptor antagonist, stimulates rat pancreatic enzyme secretion as a CCKA receptor agonist. | Höcker, M., et al. 1993. Eur J Pharmacol. 242: 105-8. PMID: 7901038
- Cholecystokinin (CCK-8S) prolongs 'unsaturated' theta-pulse induced long-term potentiation in rat hippocampal CA1 in vitro. | Balschun, D. and Reymann, KG. 1994. Neuropeptides. 26: 421-7. PMID: 7936127
- CCKB receptors mediate CCK-8S-induced activation of dorsal hippocampus CA3 pyramidal neurons: an in vivo electrophysiological study in the rat. | Gronier, B. and Debonnel, G. 1995. Synapse. 21: 158-68. PMID: 8584977
- Ethological analysis of cholecystokinin (CCKA and CCKB) receptor ligands in the elevated plus-maze test of anxiety in mice. | Johnson, NJ. and Rodgers, RJ. 1996. Psychopharmacology (Berl). 124: 355-64. PMID: 8739551
- PD-135158, a CCKB receptor antagonist, microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior. | Josselyn, SA., et al. 1996. Neurosci Lett. 209: 85-8. PMID: 8761988
- The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in rat. | Matto, V., et al. 1997. Neuropharmacology. 36: 389-96. PMID: 9175618
- CholecystokininB receptor antagonist increases food intake in rats. | Dorré, D. and Smith, GP. 1998. Physiol Behav. 65: 11-4. PMID: 9811359
Inhibitor of:
CCK-BR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 135158, 10 mg | sc-204163 | 10 mg | $235.00 | |||
PD 135158, 50 mg | sc-204163A | 50 mg | $992.00 |