PCYOX1 Antibody (25): sc-136391

PCYOX1 Antibody (25) is a mouse monoclonal IgG1 kappa light chain antibody that detects PCYOX1 protein of mouse, rat, human, and canine origin by western blotting (WB) and immunoprecipitation (IP). Anti-PCYOX1 antibody (25) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). PCYOX1 protein, also known as prenylcysteine lyase or PCL1, is a 505 amino acid FAD-dependent thioether oxidase that plays a crucial role in the metabolism of prenylated proteins. Specifically, PCYOX1 catalyzes the degradation of prenylcysteine into free cysteines and a hydrophobic isoprenoid, a process vital for cellular homeostasis and the recycling of cysteine, an important amino acid involved in various metabolic pathways. PCYOX1 is ubiquitously expressed and particularly significant in atherogenesis, where PCYOX1 may function as a very low-density lipoprotein-associated protein. Additionally, PCYOX1 is glycosylated at multiple N-glycosylation sites, which can influence stability and activity, and is encoded by a gene located on human chromosome 2p14. PCYOX1′s ability to specifically cleave the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine, underscores PCYOX1′s importance in regulating the turnover of these modified proteins, thereby impacting various signaling pathways and cellular functions.

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PCYOX1 Antibody (25) References:

1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.  |  Nagase, T., et al. 1998. DNA Res. 5: 355-64. PMID: 10048485
2. Cloning, expression, and cellular localization of a human prenylcysteine lyase.  |  Tschantz, WR., et al. 1999. J Biol Chem. 274: 35802-8. PMID: 10585463
3. Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase.  |  Tschantz, WR., et al. 2001. J Biol Chem. 276: 2321-4. PMID: 11078725
4. Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase.  |  Digits, JA., et al. 2002. J Biol Chem. 277: 41086-93. PMID: 12186880
5. Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF.  |  Mancone, C., et al. 2007. Proteomics. 7: 143-54. PMID: 17154273
6. Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme.  |  Banfi, C., et al. 2009. Proteomics. 9: 1344-52. PMID: 19253276
7. Isolation and characterization of a prenylcysteine lyase from bovine brain.  |  Zhang, L., et al. 1997. J Biol Chem. 272: 23354-9. PMID: 9287348

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PCYOX1 Antibody (25) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-PCYOX1 Antibody (25) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PCYOX1 Antibody (25) Specifications

Alternate Product Name: PCYOX1

Product Clone Name: 25

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 356-478

Epitope Target: PCYOX1

Epitope Species: human

Product Reactivity/Detection: PCYOX1

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for PCYOX1 Antibody (25): AC: Agarose, HRP: Horseradish Peroxidase