Molecular structure of PCO 400, CAS Number: 121055-10-5
PCO 400 (CAS 121055-10-5)
See product citations (2)
Alternate Names:
PCO-400
Application:
PCO 400 is an analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener
CAS Number:
121055-10-5
Molecular Weight:
299.32
Molecular Formula:
C17H17NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PCO 400 is an analog of comakalim and a selective and potent ATP-sensitive K+ channel opener. It has been shown to evoke relaxation of isolated airway smooth muscle in a dose-dependent manner. Upon intravenous injection, transient inhibition of histamine-induced bronchospasm was effected. Inhaled as a dry powder, it can suppress the development of allergic airway hyperreactivity to histamine.
PCO 400 (CAS 121055-10-5) References
- Exaggerated impact of ATP-sensitive K(+) channels on afferent arteriolar diameter in diabetes mellitus. | Ikenaga, H., et al. 2000. J Am Soc Nephrol. 11: 1199-1207. PMID: 10864575
- ATP-Sensitive potassium channels modulate glucose transport in cultured human skeletal muscle cells. | Wasada, T., et al. 2001. Endocr J. 48: 369-75. PMID: 11523909
- 50 Hz magnetic fields of varying flux intensity affect cell shape changes in invertebrate immunocytes: the role of potassium ion channels. | Ottaviani, E., et al. 2002. Bioelectromagnetics. 23: 292-7. PMID: 11948609
- Effects of a potassium channel opener (SDZ PCO 400) on guinea-pig and human pulmonary airways. | Chapman, ID., et al. 1992. Br J Pharmacol. 106: 423-9. PMID: 1382782
- K+ channel modulation of slow wave activity in the guinea-pig prostate. | Nguyen, DT., et al. 2007. Br J Pharmacol. 151: 828-36. PMID: 17533425
- Potassium channel modulators: scientific applications and therapeutic promise. | Robertson, DW. and Steinberg, MI. 1990. J Med Chem. 33: 1529-41. PMID: 2187993
- Structure-activity relationships of K+ channel openers. | Edwards, G. and Weston, AH. 1990. Trends Pharmacol Sci. 11: 417-22. PMID: 2256183
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCO 400, 20 mg | sc-200989 | 20 mg | $61.00 | |||
PCO 400, 100 mg | sc-200989A | 100 mg | $217.00 |