PCDH10 Antibody (2-YD37): sc-134415
- PCDH10 Antibody (2-YD37) is a mouse monoclonal IgG2b κ PCDH10 antibody provided at 100 µg/ml
- raised against recombinant PCDH10 protein of human origin
- recommended for detection of PCDH10 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PCDH10 Antibody (2-YD37). This work is in progress.
PCDH10 Antibody (2-YD37) is a mouse monoclonal IgG2b kappa light chain antibody that detects PCDH10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PCDH10 antibody (2-YD37) is available as a non-conjugated format. Protocadherins, including PCDH10, are crucial for the establishment and maintenance of neuronal connections in the brain, playing a significant role in neural development and synaptic function. PCDH10, also known as PCDH19 or OL-PCDH, is a 1,040 amino acid single-pass type I membrane protein characterized by six cadherin domains and one transmembrane domain. PCDH10 expression is moderate in the brain, ovary, and testis, while lower levels are found in other tissues. As a calcium-dependent cell-adhesion protein, PCDH10 functions as a tumor suppressor; PCDH10 underexpression has been linked to the progression of various carcinomas, including gastric cancer. PCDH10-mediated cell adhesion is vital for maintaining tissue architecture and preventing tumor metastasis, highlighting PCDH10′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PCDH10 Antibody (2-YD37) References:
- A striking organization of a large family of human neural cadherin-like cell adhesion genes. | Wu, Q. and Maniatis, T. 1999. Cell. 97: 779-90. PMID: 10380929
- Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. | Yagi, T. and Takeichi, M. 2000. Genes Dev. 14: 1169-80. PMID: 10817752
- Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. | Nollet, F., et al. 2000. J Mol Biol. 299: 551-72. PMID: 10835267
- Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. | Wu, Q., et al. 2001. Genome Res. 11: 389-404. PMID: 11230163
- Identification and characterization of three members of a novel subclass of protocadherins. | Wolverton, T. and Lalande, M. 2001. Genomics. 76: 66-72. PMID: 11549318
- Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. | Ying, J., et al. 2006. Oncogene. 25: 1070-80. PMID: 16247458
- Contact-dependent promotion of cell migration by the OL-protocadherin-Nap1 interaction. | Nakao, S., et al. 2008. J Cell Biol. 182: 395-410. PMID: 18644894
- Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer. | Yu, J., et al. 2009. Gastroenterology. 136: 640-51.e1. PMID: 19084528
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCDH10 Antibody (2-YD37) | sc-134415 | 100 µg/ml | $333.00 |