PCBD1 Antibody (CD-37): sc-100488

PCBD1 Antibody (CD-37) is a mouse monoclonal IgG1 kappa light chain antibody that detects PCBD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PCBD1 antibody (CD-37) is available as a non-conjugated format. PCBD1, also known as pterin-4 α-carbinolamine dehydratase, plays a crucial role in tetrahydrobiopterin biosynthesis, which is essential for phenylalanine hydroxylase system function. Specifically, PCBD1 catalyzes pterin-4α-carbinolamine conversion to quinonoid dihydrobiopterin, a vital step in regenerating 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin, necessary for phenylalanine metabolism. PCBD1 function extends beyond enzymatic activity; PCBD1 can form homodimers that act as transcriptional activators for hepatocyte nuclear factor 1 alpha (HNF-1α), influencing gene expression related to metabolic processes. Mutations in PCBD1 can lead to pterin intermediate accumulation, resulting in metabolic disorders such as primapterinuria, characterized by elevated phenylalanine levels and 7-substituted pterin excretion. This highlights PCBD1′s significance in metabolic regulation and potential implications for human health, particularly in conditions like phenylketonuria.

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PCBD1 Antibody (CD-37) References:

1. Molecular evidence that halo in Sutton's naevus is not vitiligo.  |  Schallreuter, KU., et al. 2003. Arch Dermatol Res. 295: 223-8. PMID: 14530988
2. Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo.  |  Schallreuter, KU., et al. 2004. Biochem Biophys Res Commun. 315: 502-8. PMID: 14766237
3. In vivo and in vitro evidence for autocrine DCoH/HNF-1alpha transcription of albumin in the human epidermis.  |  Hasse, S., et al. 2005. Exp Dermatol. 14: 182-7. PMID: 15740590
4. A nhaD Na+/H+ antiporter and a pcd homologues are among the Rhodothermus marinus complex I genes.  |  Melo, AM., et al. 2005. Biochim Biophys Acta. 1709: 95-103. PMID: 16023073
5. Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo.  |  Pey, AL., et al. 2006. FASEB J. 20: 2130-2. PMID: 16935936
6. Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues.  |  Cameron, S., et al. 2008. Mol Biochem Parasitol. 158: 131-8. PMID: 18215430
7. Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms.  |  Naponelli, V., et al. 2008. Plant Physiol. 146: 1515-27. PMID: 18245455
8. Hyperphenylalaninemia with high levels of 7-biopterin is associated with mutations in the PCBD gene encoding the bifunctional protein pterin-4a-carbinolamine dehydratase and transcriptional coactivator (DCoH).  |  Thöny, B., et al. 1998. Am J Hum Genet. 62: 1302-11. PMID: 9585615

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PCBD1 Antibody (CD-37) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PCBD1 Antibody (CD-37) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PCBD1 Antibody (CD-37) Specifications

Alternate Product Name: PCBD1

Product Clone Name: CD-37

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-105

Epitope Target: PCBD1

Epitope Species: human

Product Reactivity/Detection: PCBD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PCBD1 Antibody (CD-37): N/A

The preferred PCBD1 antibody is PCBD1 Antibody (E-7): sc-518184.