Molecular structure of PCA 4248, CAS Number: 123875-01-4
PCA 4248 (CAS 123875-01-4)
Alternate Names:
Methyl 2-(phenylsulfanyl)ethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Application:
PCA 4248 is a competitive inhibitor of PAF at the PAF-R level
CAS Number:
123875-01-4
Purity:
98%
Molecular Weight:
361.4
Molecular Formula:
C19H23NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PCA 4248 is a dihydropyridine that may act to be a competitive inhibitor of platelet-activating factor (PAF). Mechanistic studies suggest that this compound acts as a competitive antagonist at the PAF-R (PAF receptor) level therefore preventing PAF binding to the receptor. PCA 4248 has also been reported to halt serotonin secretion caused by PAF and also block the increase of eosinophils, neutrophils, and mononuclear cells that result after PAF exposure.
PCA 4248 (CAS 123875-01-4) References
- Microglial calcium responses to platelet-activating factor are inhibited by analogue CAS 99103-16-9 and dihydropyridine PCA 4248 but not by ginkgolide A. | Ranasinghe, S. and Bolsover, S. 2004. Basic Clin Pharmacol Toxicol. 95: 87-91. PMID: 15379786
- Enterolobin induces rat paw oedema independently of PAF-acether. | Castro-Faria-Neto, HC., et al. 1991. Mem Inst Oswaldo Cruz. 86 Suppl 2: 129-31. PMID: 1841984
- Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice. | Singh, TP., et al. 2011. Am J Pathol. 178: 699-708. PMID: 21281802
- 1,4-Dihydropyridines, a new class of platelet-activating factor receptor antagonists: in vitro pharmacologic studies. | Ortega, MP., et al. 1990. J Pharmacol Exp Ther. 255: 28-33. PMID: 2170624
- Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies. | Fernández-Gallardo, S., et al. 1990. J Pharmacol Exp Ther. 255: 34-9. PMID: 2170626
- Platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with Leishmania (Viannia) braziliensis. | Borges, AF., et al. 2017. Pathog Dis. 75: PMID: 28830073
- A Possible Role for Platelet-Activating Factor Receptor in Amyotrophic Lateral Sclerosis Treatment. | Briones, MRS., et al. 2018. Front Neurol. 9: 39. PMID: 29472887
- PCA-4248, a PAF receptor antagonist, inhibits PAF-induced phosphoinositide turnover. | Catalán, RE., et al. 1995. Eur J Pharmacol. 290: 183-8. PMID: 7589212
- Compound PCA-4248 interferes with bronchopulmonary anaphylaxis and with in vitro hyperresponsiveness to platelet-activating factor. | Desquand, S., et al. 1993. Eur J Pharmacol. 235: 101-8. PMID: 7686102
- Studies on the mechanism of PAF-induced vasopermeability in rat lungs. | de Lima, WT., et al. 1995. Prostaglandins Leukot Essent Fatty Acids. 52: 245-9. PMID: 7784472
- Interference of PCA 4248, a novel PAF receptor antagonist, with antigen-induced paw edema in mice. | Amorim, CZ., et al. 1993. Eur J Pharmacol. 236: 301-4. PMID: 8319756
- New 4-alkyl-1,4-dihydropyridines: evaluation of photostability and phototoxic potential. | Cortés, MP., et al. 1993. J Photochem Photobiol B. 19: 135-8. PMID: 8377076
- Interference of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen. | Martins, MA., et al. 1993. Eur J Pharmacol. 237: 17-22. PMID: 8395390
- Platelet-activating factor antagonists. | Negro Alvarez, JM., et al. 1997. Allergol Immunopathol (Madr). 25: 249-58. PMID: 9395010
Inhibitor of:
IRAK-1, PAF-R, and PAFAH1B2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCA 4248, 10 mg | sc-203446 | 10 mg | $100.00 |