Molecular structure of PB 28 dihydrochloride, CAS Number: 172906-90-0
PB 28 dihydrochloride (CAS 172907-03-8)
See product citations (2)
Application:
PB 28 dihydrochloride is a high affinity selective σ2 receptor agonist
CAS Number:
172907-03-8
Purity:
>99%
Molecular Weight:
443.5
Molecular Formula:
C24H38N2O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PB 28 dihydrochloride is a high affinity selective sigma2 receptor Activators (Ki values are 0.8 and 15.2 nM for sigma2 and sigma1 receptors respectively) that displays minimal affinity at other receptors. PB 28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 muM respectively). PB 28 dihydrochloride also displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
PB 28 dihydrochloride (CAS 172907-03-8) References
- A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder. | Colabufo, NA., et al. 2003. Naunyn Schmiedebergs Arch Pharmacol. 368: 106-12. PMID: 12879208
- Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines. | Colabufo, NA., et al. 2004. Naunyn Schmiedebergs Arch Pharmacol. 370: 106-13. PMID: 15322732
- Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice. | Kitanaka, J., et al. 2009. Psychopharmacology (Berl). 203: 781-92. PMID: 19052726
- Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28). | Berardi, F., et al. 2009. J Med Chem. 52: 7817-28. PMID: 19842660
- 1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 (sigma1) and sigma-2 (sigma2) receptor ligands: a review. | Berardi, F., et al. 2009. Cent Nerv Syst Agents Med Chem. 9: 205-19. PMID: 20021355
- Could sigma receptor ligands be a treatment for methamphetamine addiction? | Rodvelt, KR. and Miller, DK. 2010. Curr Drug Abuse Rev. 3: 156-62. PMID: 21054260
- Straub tail reaction in mice treated with σ(1) receptor antagonist in combination with methamphetamine. | Kitanaka, J., et al. 2012. Brain Res. 1482: 40-6. PMID: 22981417
- Evidences for the involvement of sigma receptors in antidepressant like effect of quetiapine in mice. | Kotagale, NR., et al. 2013. Eur J Pharmacol. 702: 180-6. PMID: 23399765
- Agmatine attenuates neuropathic pain in sciatic nerve ligated rats: modulation by hippocampal sigma receptors. | Kotagale, NR., et al. 2013. Eur J Pharmacol. 714: 424-31. PMID: 23872381
- The cognition-enhancing activity of E1R, a novel positive allosteric modulator of sigma-1 receptors. | Zvejniece, L., et al. 2014. Br J Pharmacol. 171: 761-71. PMID: 24490863
- Sigma-2 receptor ligands: neurobiological effects. | Guo, L. and Zhen, X. 2015. Curr Med Chem. 22: 989-1003. PMID: 25620095
- Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression. | Aguinaga, D., et al. 2018. Front Mol Neurosci. 11: 17. PMID: 29483862
- Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor. | Hao, Y., et al. 2022. Cell Chem Biol. 29: 625-635.e3. PMID: 34678160
- Analysis of Mitochondrial Function in Cell Membranes as Indicator of Tissue Vulnerability to Drugs in Humans. | Elexpe, A., et al. 2022. Biomedicines. 10: PMID: 35625717
- New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives. | Berardi, F., et al. 1996. J Med Chem. 39: 176-82. PMID: 8568804
Activator of:
Sigma Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PB 28 dihydrochloride, 10 mg | sc-204834 | 10 mg | $140.00 | |||
PB 28 dihydrochloride, 50 mg | sc-204834A | 50 mg | $575.00 |