Molecular structure of PAz-PC, CAS Number: 117746-89-1
PAz-PC (CAS 117746-89-1)
Alternate Names:
1-Palmitoyl-2-Azelaoyl PC; Azelaoyl PC
Application:
PAz-PC is a potent PPARγ receptor agonist
CAS Number:
117746-89-1
Molecular Weight:
665.80
Molecular Formula:
C33H64NO10P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PAz-PC is a potent PPARgamma receptor agonist which competes for the thiazoladinedione binding site. More potent than 15-deoxy-Delta12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor. Confers CD36 scavenger receptor binding affinity to LDL and may be one of the important structural determinants of oxLDL.
PAz-PC (CAS 117746-89-1) References
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- A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. | Podrez, EA., et al. 2002. J Biol Chem. 277: 38517-23. PMID: 12145296
- Interaction of cytochrome c with 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine: evidence for acyl chain reversal. | Mattila, JP., et al. 2008. Langmuir. 24: 4157-60. PMID: 18315024
- Anti-inflammatory peptides grab on to the whiskers of atherogenic oxidized lipids. | Epand, RF., et al. 2009. Biochim Biophys Acta. 1788: 1967-75. PMID: 19559666
- The activation of liver X receptors inhibits toll-like receptor-9-induced foam cell formation. | Sorrentino, R., et al. 2010. J Cell Physiol. 223: 158-67. PMID: 20049870
- 1-Palmitoyl-2-(9'-oxononanoyl)-sn-glycero-3-phosphocholine, an oxidized phospholipid, accelerates Finnish type familial gelsolin amyloidosis in vitro. | Mahalka, AK., et al. 2011. Biochemistry. 50: 4877-89. PMID: 21545139
- Anti-angiogenesis therapy in the Vx2 rabbit cancer model with a lipase-cleavable Sn 2 taxane phospholipid prodrug using α(v)β₃-targeted theranostic nanoparticles. | Pan, D., et al. 2014. Theranostics. 4: 565-78. PMID: 24723979
- Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. | Berg, EL., et al. 2015. Int J Mol Sci. 16: 1008-29. PMID: 25569083
- A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy. | Pan, D., et al. 2015. Nanomedicine (Lond). 10: 241-51. PMID: 25600969
- Small Molecule MYC Inhibitor Conjugated to Integrin-Targeted Nanoparticles Extends Survival in a Mouse Model of Disseminated Multiple Myeloma. | Soodgupta, D., et al. 2015. Mol Cancer Ther. 14: 1286-1294. PMID: 25824336
- Oxidized phosphatidylcholines suggest oxidative stress in patients with medium-chain acyl-CoA dehydrogenase deficiency. | Najdekr, L., et al. 2015. Talanta. 139: 62-6. PMID: 25882409
- Formation of Aldehydic Phosphatidylcholines during the Anaerobic Decomposition of a Phosphatidylcholine Bearing the 9-Hydroperoxide of Linoleic Acid. | Onyango, AN. 2016. Biomed Res Int. 2016: 8218439. PMID: 27366754
- Platelet-activating factor acetylhydrolases: An overview and update. | Kono, N. and Arai, H. 2019. Biochim Biophys Acta Mol Cell Biol Lipids. 1864: 922-931. PMID: 30055287
- Preferential hydrolysis of oxidized phospholipids by peritoneal fluid of rats treated with casein. | Itabe, H., et al. 1988. Biochim Biophys Acta. 963: 192-200. PMID: 3196725
Activator of:
PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAz-PC, 1 mg | sc-202757 | 1 mg | $82.00 | |||
PAz-PC, 5 mg | sc-202757A | 5 mg | $300.00 | |||
PAz-PC, 10 mg | sc-202757B | 10 mg | $450.00 | |||
PAz-PC, 50 mg | sc-202757C | 50 mg | $1850.00 |