Paxillinol
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Paxillinol is a chemical that functions as a key regulator of cell adhesion and migration. It plays a crucial role in the organization of actin cytoskeleton and focal adhesions, contributing to the maintenance of cell shape and motility. Paxillinol interacts with various signaling molecules, such as focal adhesion kinase and vinculin, to modulate the assembly and disassembly of focal adhesions. Paxillinol participates in the regulation of cell proliferation and survival by influencing the activity of downstream signaling pathways. Paxillinol acts as a scaffold protein, facilitating the recruitment and activation of other signaling molecules at focal adhesions. Its mode of action involves the coordination of intracellular signaling events that are essential for cell movement and tissue remodeling. Paxillinol plays a significant role in the dynamic regulation of cellular processes related to adhesion, migration, and cytoskeletal organization.
Paxillinol References
- Delayed rectifier potassium channels contribute to the depressed pulmonary artery contractility in pneumonia. | Yaghi, A., et al. 2002. J Appl Physiol (1985). 93: 957-65. PMID: 12183491
- Glutamate-induced cell death in HT22 mouse hippocampal cells is attenuated by paxilline, a BK channel inhibitor. | Kulawiak, B. and Szewczyk, A. 2012. Mitochondrion. 12: 169-72. PMID: 22240184
- What do we not know about mitochondrial potassium channels? | Laskowski, M., et al. 2016. Biochim Biophys Acta. 1857: 1247-1257. PMID: 26951942
- Mitigating effect of paxilline against injury produced by Cd2+ in rat pheochromocytoma PC12 and ascites hepatoma AS-30D cells. | Belyaeva, EA. and Sokolova, TV. 2020. Ecotoxicol Environ Saf. 196: 110519. PMID: 32244116
- Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. | Knaus, HG., et al. 1994. Biochemistry. 33: 5819-28. PMID: 7514038
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Paxillinol, 2 mg | sc-205792 | 2 mg | $153.00 |