Patulin-13C3 (CAS 748133-69-9)

Patulin-13C3, listed under the CAS number 748133-69-9, is a stable isotope-labeled form of patulin, a mycotoxin originally produced by several species of fungi, notably Penicillium, Aspergillus, and Byssochlamys. This specific derivative incorporates three ^13C isotopes, making it an invaluable tool for scientific studies, particularly those involving tracking and analyzing the metabolic pathways and environmental fate of patulin through isotope-ratio mass spectrometry. The primary mechanism of action of patulin involves its interaction with thiol groups in biomolecules, leading to the disruption of essential biochemical processes. Patulin-13C3, by mimicking the behavior of the unlabeled compound, is crucial for understanding how patulin binds to cellular components, influencing cellular redox status and inducing oxidative stress. This labeled version allows researchers to quantify the uptake, distribution, and biotransformation of patulin in biological systems with higher precision. In research, Patulin-13C3 serves as a traceable standard that facilitates the development of detection methods and the study of patulin′s toxicological impact on cells without the interference from the natural abundance of ^12C, thus providing clearer insights into the dynamics of its interactions at the molecular level. These studies are essential for assessing risks associated with exposure and for validating methodologies aimed at detecting and quantifying patulin in environmental and biological samples.