Parvodicin complex (CAS 187888-13-7)

The Parvodicin complex, registered under the CAS number 187888-13-7, comprises a group of closely related glycopeptide antibiotics derived from Actinomadura parvosata. This complex is structurally characterized by multiple peptide bonds and sugar moieties, which contribute to its potent activity. The primary mode of action of the compounds within the Parvodicin complex involves the inhibition of cell wall synthesis in gram-positive bacteria. They achieve this by binding with high affinity to the D-alanyl-D-alanine termini of peptidoglycan precursors, a critical interaction that prevents the transglycosylation and transpeptidation reactions necessary for the proper formation of the bacterial cell wall. This interaction not only inhibits the growth of bacteria but also leads to cell lysis due to structural weakness in the cell wall. In research contexts, the Parvodicin complex has been a valuable tool for studying the mechanisms of action of glycopeptide antibiotics and their interactions with bacterial cell wall precursors. It has also been utilized in studies focused on understanding bacterial resistance, particularly how changes in the target sites of glycopeptide antibiotics can affect their binding and efficacy. These studies are crucial for advancing the field of microbiology and developing new strategies to manage resistant strains of bacteria, enhancing our understanding of microbial dynamics and the potential for innovative antibiotic development.