Date published: 2026-2-11

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Paroxol (CAS 105812-81-5)

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Alternate Names:
(4R,3S)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol; (3S-trans)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol; (−)-trans-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine;[(3S,4R)-4-(4-Fluorophenyl)-1-methylpiperidin-3-yl]methanol
CAS Number:
105812-81-5
Molecular Weight:
223.29
Molecular Formula:
C13H18FNO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Paroxol emerges as a vital organic compound widely employed in diverse scientific research applications. This compound exhibits a distinctive structure composed of a central piperidine ring, a methyl group, and a hydroxymethyl group, all interconnected with a 4-fluorophenyl group. Paroxol finds utility across a diverse array of scientific research applications. It has been effectively employed as a catalyst in synthesizing various organic compounds, including amides, esters, and amines. Furthermore, it serves as a ligand in the synthesis of coordination compounds. While the precise mechanism of action of Paroxol remains incompletely understood, it is believed to function as a catalyst in the synthesis of diverse organic compounds. Specifically, the 4-fluorophenyl group is thought to interact with substrate molecules, facilitating accelerated and efficient reactions. Additionally, the hydroxymethyl group is believed to provide added stability to the compound, enabling it to maintain its structural integrity across various environments.


Paroxol (CAS 105812-81-5) References

  1. Stereoselectiveseparation of racemic trans-paroxol, N-methylparoxetine and paroxetine containing two chiral carbon centres by countercurrent chromatography.  |  Lv, L., et al. 2018. J Chromatogr A. 1570: 99-108. PMID: 30097343
  2. Enantioseparation of five racemic N-alkyl drugs by reverse phase HPLC using sulfobutylether-β-cyclodextrin as a chiral mobile phase additive.  |  Chen, B., et al. 2022. J Sep Sci. 45: 1847-1855. PMID: 35322921
  3. Analytical enantioseparation of N-alkyl drugs by reversed-phase liquid chromatography with carboxymethyl-β-cyclodextrin as mobile phase additive.  |  You, H., et al. 2023. Chirality. 35: 58-66. PMID: 36345792

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Paroxol, 1 g

sc-219562A
1 g
$75.00

Paroxol, 5 g

sc-219562
5 g
$186.00