Molecular structure of Paroxetine maleate, CAS Number: 64006-44-6
Paroxetine maleate (CAS 64006-44-6)
Application:
Paroxetine maleate is a selective serotonin uptake inhibitor
CAS Number:
64006-44-6
Molecular Weight:
445.44
Molecular Formula:
C19H20FNO3•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Paroxetine maleate displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM).
Paroxetine maleate (CAS 64006-44-6) References
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- High-performance liquid chromatographic determination of mepyramine maleate, pheniramine maleate and phenylpropanolamine hydrochloride in tablets and drops. | el-Gizawy, SM. and Ahmed, Ael H. 1987. Analyst. 112: 867-9. PMID: 3619056
- A comparative study on the antihistaminic potencies of promethazine hydrochloride, mepyramine maleate and pheniramine maleate in dogs. | Gopalan, S. and Nayar, CK. 1971. Indian Vet J. 48: 295-301. PMID: 4397014
- The actions of cimetidine hydrochloride and mepyramine maleate in rat adjuvant arthritis. | Al-Haboubi, HA. and Zeitlin, IJ. 1982. Eur J Pharmacol. 78: 175-85. PMID: 7075670
- Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. | Owens, MJ., et al. 1997. J Pharmacol Exp Ther. 283: 1305-22. PMID: 9400006
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Paroxetine maleate, 10 mg | sc-203658 | 10 mg | $172.00 | |||
Paroxetine maleate, 50 mg | sc-203658A | 50 mg | $712.00 |