Molecular structure of Paroxetine HCl, CAS Number: 78246-49-8
Paroxetine HCl (CAS 78246-49-8)
See product citations (2)
Alternate Names:
Paroxat
Application:
Paroxetine HCl is a highly potent and selective serotonin (5-HT) uptake inhibitor
CAS Number:
78246-49-8
Purity:
≥98%
Molecular Weight:
365.82
Molecular Formula:
C19H20FNO3•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Paroxetine HCl is used in various research applications to study its impact on neurotransmitter systems, particularly serotonin reuptake inhibition. As a research tool, it allows for the investigation of the effects of serotonin availability on receptor regulation. In neurochemical research, Paroxetine HCl is used to understand the molecular underpinnings of neurotransmitter release and reuptake, as well as the downstream effects on neural circuitry. This compound is also employed in studies examining the adaptation of the serotonergic system over time, including changes in receptor expression and function. Additionally, Paroxetine HCl is of interest in the field of neurobiology for its relation to synaptic plasticity in experimental models.
Paroxetine HCl (CAS 78246-49-8) References
- Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study. | Di Girolamo, E., et al. 1999. J Am Coll Cardiol. 33: 1227-30. PMID: 10193720
- A pilot trial assessing the efficacy of paroxetine hydrochloride (Paxil) in controlling hot flashes in breast cancer survivors. | Stearns, V., et al. 2000. Ann Oncol. 11: 17-22. PMID: 10690382
- Paroxetine: a review. | Bourin, M., et al. 2001. CNS Drug Rev. 7: 25-47. PMID: 11420571
- Perinatal outcome following third trimester exposure to paroxetine. | Costei, AM., et al. 2002. Arch Pediatr Adolesc Med. 156: 1129-32. PMID: 12413342
- Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. | Fujishiro, J., et al. 2002. Eur J Pharmacol. 454: 183-8. PMID: 12421645
- Spectrofluorimetric determination of paroxetine hydrochloride in its formulations and human plasma. | Alarfaj, N., et al. 2006. Chem Pharm Bull (Tokyo). 54: 564-6. PMID: 16595967
- Pharmacokinetics of paroxetine, a selective serotonin reuptake inhibitor, in Grey parrots (Psittacus erithacus erithacus): influence of pharmaceutical formulation and length of dosing. | van Zeeland, YR., et al. 2013. J Vet Pharmacol Ther. 36: 51-8. PMID: 22435778
- Development and comparative evaluation of in vitro, in vivo properties of novel controlled release compositions of paroxetine hydrochloride hemihydrate as against Geomatrix™ platform technology. | Khatavkar, UN., et al. 2013. Drug Dev Ind Pharm. 39: 1175-86. PMID: 22607046
- Identification and characterization of stoichiometric and nonstoichiometric hydrate forms of paroxetine HCl: reversible changes in crystal dimensions as a function of water absorption. | Pina, MF., et al. 2012. Mol Pharm. 9: 3515-25. PMID: 23051151
- Generation of hydrate forms of paroxetine HCl from the amorphous state: an evaluation of thermodynamic and experimental predictive approaches. | Pina, MF., et al. 2015. Int J Pharm. 481: 114-24. PMID: 25592956
- Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. | Thomas, DR., et al. 1987. Psychopharmacology (Berl). 93: 193-200. PMID: 2962217
- Paroxetine effects in adult male rat colon: Focus on gut steroidogenesis and microbiota. | Diviccaro, S., et al. 2022. Psychoneuroendocrinology. 143: 105828. PMID: 35700562
- Fabrication of solid lipid nanoparticles-based patches of paroxetine and their ex-vivo permeation behaviour. | Pervaiz, F., et al. 2023. Artif Cells Nanomed Biotechnol. 51: 108-119. PMID: 36855254
- Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. | Owens, MJ., et al. 1997. J Pharmacol Exp Ther. 283: 1305-22. PMID: 9400006
Inhibitor of:
CYP2D6, NOS, and ST.Substrate of:
CYP2D6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Paroxetine HCl, 20 mg | sc-201141 | 20 mg | $117.00 | |||
Paroxetine HCl, 100 mg | sc-201141A | 100 mg | $445.00 |