PARD3A Antibody (4G5): sc-293213
- PARD3A Antibody (4G5) is a mouse monoclonal IgG2a κ PARD3A antibody provided at 100 µg/ml
- raised against a partial recombinant protein mappein within amino acids 181-290 of PARD3A of human origin
- recommended for detection of PARD3A of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PARD3A Antibody (4G5). This work is in progress.
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PARD3A Antibody (4G5) is a mouse monoclonal IgG2a kappa light chain antibody that detects PARD3A protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PARD3A antibody (4G5) is available as a non-conjugated format. PARD3A protein, also known as partitioning-defective 3, Baz, or ASIP, is a crucial component in maintaining cellular asymmetry, which is vital for proper development of multicellular organisms. This 1,356 amino acid protein features three PDZ domains and is part of the PAR3 family, playing a significant role in asymmetric cell division and polarized growth. PARD3A is predominantly expressed in various tissues and colocalizes with PARD6A/B and protein kinase C ι at epithelial tight junctions, functioning as an adapter protein essential for normal tight junction formation at epithelial cell-cell contacts. PARD3A undergoes alternative splicing, resulting in at least ten isoforms, including isoform A, isoform B, isoform C, isoform D, isoform E, isoform F, isoform Lb, isoform Sa, isoform Sb, and isoform 10, each potentially contributing to diverse cellular functions and regulatory mechanisms.
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PARD3A Antibody (4G5) References:
- The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. | Joberty, G., et al. 2000. Nat Cell Biol. 2: 531-9. PMID: 10934474
- Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. | Suzuki, A., et al. 2001. J Cell Biol. 152: 1183-96. PMID: 11257119
- Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. | Shi, SH., et al. 2003. Cell. 112: 63-75. PMID: 12526794
- A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. | Iden, S., et al. 2006. EMBO Rep. 7: 1239-46. PMID: 17057644
- The polarity protein Par-3 directly interacts with p75NTR to regulate myelination. | Chan, JR., et al. 2006. Science. 314: 832-6. PMID: 17082460
- Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair. | Fang, L., et al. 2007. Cell Res. 17: 100-16. PMID: 17287830
- A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. | Tawk, M., et al. 2007. Nature. 446: 797-800. PMID: 17392791
- Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis. | Kim, M., et al. 2007. J Cell Sci. 120: 2309-17. PMID: 17606986
- A critical step for postsynaptic F-actin organization: regulation of Baz/Par-3 localization by aPKC and PTEN. | Ramachandran, P., et al. 2009. Dev Neurobiol. 69: 583-602. PMID: 19472188
- Expression of partitioning defective 3 (Par-3) for predicting extrahepatic metastasis and survival with hepatocellular carcinoma. | Jan, YJ., et al. 2013. Int J Mol Sci. 14: 1684-97. PMID: 23322019
- Dual function of partitioning-defective 3 in the regulation of YAP phosphorylation and activation. | Zhang, P., et al. 2016. Cell Discov. 2: 16021. PMID: 27462467
- High expression of partitioning defective 3-like protein is associated with malignancy in colorectal cancer. | Li, T., et al. 2017. Tumour Biol. 39: 1010428317698393. PMID: 28443499
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PARD3A Antibody (4G5) | sc-293213 | 100 µg/ml | $322.00 |