Paraoxon (CAS 311-45-5)
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Paraoxon, an organophosphate pesticide and metabolite of parathion, is widely recognized for its potent role as an irreversible inhibitor of the enzyme acetylcholinesterase. This enzyme inhibition is central to its mechanism of action, leading to the accumulation of acetylcholine at nerve synapses and neuromuscular junctions. Paraoxon′s significant inhibition properties make it a useful surrogate for studying the effects and mechanisms of similar organophosphates often associated with chemical warfare agents. Additionally, its interaction with environmental science is notable, especially in the context of its degradation pathways. When Paraoxon is immobilized on substrates such as quartz or glass, it can be efficiently degraded in the presence of titania nanoparticles. This property is utilized in research focused on understanding and developing advanced methods for the detoxification and environmental management of hazardous substances.
Paraoxon (CAS 311-45-5) References
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- Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface. | Franklin, MC., et al. 2016. Proteins. 84: 1246-56. PMID: 27191504
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- Determination of Picomolar Concentrations of Paraoxon in Human Urine by Fluorescence-Based Enzymatic Assay. | Cetrangolo, GP., et al. 2019. Sensors (Basel). 19: PMID: 31703397
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- A novel, biocompatible and electrocatalytic stearic acid/nanosilver modified glassy carbon electrode for the sensing of paraoxon pesticide in food samples and commercial formulations. | Kumaravel, A., et al. 2020. Food Chem. 323: 126814. PMID: 32334304
- A simple enzymeless approach for Paraoxon determination using imidazole-functionalized carbon nanotubes. | de Oliveira, GA., et al. 2020. Mater Sci Eng C Mater Biol Appl. 116: 111140. PMID: 32806307
- High-performance electrochemical sensing of hazardous pesticide Paraoxon using BiVO4 nano dendrites equipped catalytic strips. | Gopi, PK., et al. 2022. Chemosphere. 288: 132511. PMID: 34688713
- Smartphone-assisted bioenzyme-nanozyme-chromogen all-in-one test strip with enhanced cascade signal amplification for convenient paraoxon sensing. | Zhu, H., et al. 2022. Biosens Bioelectron. 215: 114583. PMID: 35932555
- CeO2@NC nanozyme with robust dephosphorylation ability of phosphotriester: A simple colorimetric assay for rapid and selective detection of paraoxon. | Gai, P., et al. 2023. Biosens Bioelectron. 220: 114841. PMID: 36323162
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Paraoxon, 1 g | sc-208151 | 1 g | $800.00 | |||
Paraoxon, 5 g | sc-208151A | 5 g | $2712.00 | |||
Paraoxon, 10 g | sc-208151B | 10 g | $5202.00 |