Paraoxon CAS: 311-45-5
MF: C10H14NO6P
MW: 275.20

Paraoxon (CAS 311-45-5)

Paraoxon | CAS 311-45-5 is rated 5.0 out of 5 by 1.
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Alternate Names: Paraoxon is also known as Diethyl p-nitrophenyl phosphate.
Application: Paraoxon is an organophosphate pesticide, parathion metabolite, and acetylcholinesterase inhibitor.
CAS Number: 311-45-5
Molecular Weight: 275.20
Molecular Formula: C10H14NO6P
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Paraoxon is an organophosphate pesticide. Paraoxon can function as a surrogate of chemical warfare agents. Using titania nanoparticles, Paraoxon can undergo degradation while immobilized on quartz or glass substrates. Paraoxon is a known metabolite of parathion. Paraoxon also is used as an irreversible acetylcholinesterase inhibitor.


References

1. Pickering, W.R., et al.: Biochem. Pharmacol., 16, 1183 (1967)
2. Photocatalytic degradation of paraoxon-ethyl in aqueous solution using titania nanoparticulate film Prasad.K.G, et al. Thin Solid Films 520(17), 5597-5601, (2012)
3. Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators Pohanka M, et al. Talanta 77(1), 451-454, (2008)
4. S K Falahati-Pour et. al
Journal of applied microbiology, 118(4), undefined (2015-1-8)
5. Nobuhiko Tokuriki et. al
Nature communications, 3, undefined (2012-12-6)

Physical State :
Liquid
Solubility :
Soluble in chloroform, ether, hexane, and water (2.4 mg/ml).
Storage :
Store at 4° C
Melting Point :
82.58° C (Predicted)
Boiling Point :
169-170° C
Density :
1.27 g/mL at 25° C (lit.)
Refractive Index :
n20D 1.51 (lit.)
IC50 :
Acetylcholinesterase: IC50 = 13 nM (mouse); Carbonic anhydrase II: IC50 = 59 nM (human)
pK Values :
pKa: 8.5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TC2275000
PubChem CID :
9395
Merck Index :
14: 7030
MDL Number :
MFCD00007316
EC Number :
206-221-0
Beilstein Registry :
1915526
SMILES :
CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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Paraoxon (CAS 311-45-5)  Product Citations

See how others have used Paraoxon (CAS 311-45-5). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26919159  Ivanišević, J.|Kotur-Stevuljević, J.|Stefanović, A.|Spasić, S.|Vučinić Mihailović, V.|Videnović Ivanov, J.|Jelić-Ivanović, Z.| et al. 2016. Eur. J. Clin. Invest. 46: 418-24.

PMID: # 24868095  Sakai, K. et al. 2014. J. Lipid Res. 55: 2033-40.

PMID: # 32476903  Sarcoidosis Vasc Diffuse Lung Dis. 198-205.

Citations 1 to 3 of 3 total

I want to dissolve it in DMSO is there a protocol for doing that?

Asked by: Manish3303
Thank you for your question. Unfortunately we do not have any data on solubility in DMSO.
Answered by: Tech Service
Date published: 2020-01-23

SDS description says it is a liquid, size is 1 gram, is there a liquid measurement associated?

Asked by: Hassie
Thank you for your question. According to our Certificate of Analysis, Paraoxon is provided as an oil. There is no solvent at all and no liquid measurement is provided.
Answered by: Technical Support
Date published: 2017-11-15

Is there a substance or solvent that can be used to dissolve Paraoxon?

Asked by: 13punMA
Thank you for your question. Yes, Paraoxon can be dissolved in ether or other organic solvents.
Answered by: Technical Support
Date published: 2017-03-10
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Rated 5 out of 5 by from Jan Jan, YH. et al. (PubMed 26212258) demonstrate that menadione is a potent inhibitor of cytochrome P450-mediated metabolism of parathion to its cytotoxic metabolite Paraoxon, a cholinesterase inhibitor. -SCBT Publication Review
Date published: 2015-02-10
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