PAPA NONOate (CAS 146672-58-4)
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PAPA NONOate is a diazeniumdiolate small molecule NO donor with a reported NO release half-life of 77 min (22-25degC). NO release from PAPA NONOate has demonstrated regulation of caspase-3 activity and suppression of the caspase apoptotic cascade via inhibition of S-nitrosylation of the Cys-163 residue on caspase-3. In NO-vacant NT2N cells, NO release from PAPA NONOate produced cell death through apoptotic signaling, as contrasted with the necrotic injury produced by peroxynitrite exposure. NO release from PAPA NONOate is shown to increase cGMP in a model of ischemic lung injury, suggesting that the protective effects of NO against ischemic injury are cGMP-mediated. PAPA NONOate also demonstrated inhibition of protein synthesis in A375 melanoma cells through release of NO, inhibiting thymidine incorporation by 50% (44 muM) and producing a cytostatic effect. PAPA NONOate exhibits anti-inflammatory, antioxidant, and neuroprotective properties. By inhibiting certain enzymes like cyclooxygenase-2 (COX-2), which contributes to inflammation, and activating receptors such as cannabinoid receptors involved in pain regulation, inflammation, and other physiological processes, Papa Nonoate exerts its effects.
PAPA NONOate (CAS 146672-58-4) References
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- Mechanistic studies of oxidative decomposition of Angeli's salt and PAPA NONOate. | Bobko, AA. and Khramtsov, VV. 2014. Nitric Oxide. 40: 92-8. PMID: 24947085
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PAPA NONOate, 5 mg | sc-202272 | 5 mg | $38.00 | |||
PAPA NONOate, 25 mg | sc-202272A | 25 mg | $111.00 |