Molecular structure of Pantoprazole, CAS Number: 102625-70-7
Pantoprazole (CAS 102625-70-7)
See product citations (2)
Alternate Names:
5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole
Application:
Pantoprazole is an inhibitor of gastric H+/K+-ATPase
CAS Number:
102625-70-7
Purity:
98%
Molecular Weight:
383.37
Molecular Formula:
C16H15F2N3O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pantoprazole is a proton pump inhibitor that functions by irreversibly binding to the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. This binding inhibits the final step of acid production, leading to a reduction in both basal and stimulated gastric acid secretion. At the molecular level, pantoprazole covalently and selectively targets the proton pump, preventing the release of hydrogen ions into the stomach lumen. This mechanism of action effectively suppresses gastric acid secretion, making pantoprazole may be useful for studying the regulation of acid production in experimental applications. Pantoprazole′s specific mechanism of action at the cellular level allows for the investigation of the physiological and biochemical processes involved in acid secretion.
Pantoprazole (CAS 102625-70-7) References
- Pantoprazole reduces vascular relaxation in-vitro and ex-vivo and interferes with blood coagulation in an animal model. | Arafah, AM., et al. 2018. Biomed Pharmacother. 104: 537-541. PMID: 29803168
- Pantoprazole Induces Mitochondrial Apoptosis and Attenuates NF-κB Signaling in Glioma Cells. | Geeviman, K., et al. 2018. Cell Mol Neurobiol. 38: 1491-1504. PMID: 30302629
- Uroprotective effect of pantoprazole against cyclophosphamide-induced cystitis in mice. | Engin, S., et al. 2019. Support Care Cancer. 27: 4273-4281. PMID: 30874926
- Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress. | Ismail, RS., et al. 2020. Naunyn Schmiedebergs Arch Pharmacol. 393: 1161-1171. PMID: 31950223
- Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole. | Abed, MN., et al. 2020. Pharmacology. 105: 645-651. PMID: 32289807
- Role of Genetic Polymorphisms of Cytochrome P450 2C19 in Pantoprazole Metabolism and Pantoprazole-based Helicobacter pylori Eradication Regimens. | Jonaitis, P., et al. 2020. Curr Drug Metab. 21: 830-837. PMID: 32407266
- Pantoprazole, a proton-pump inhibitor, impairs human sperm motility and capacitation in vitro. | Escoffier, J., et al. 2020. Andrology. 8: 1795-1804. PMID: 32609951
- Pantoprazole impairs fracture healing in aged mice. | Menger, MM., et al. 2020. Sci Rep. 10: 22376. PMID: 33361800
- Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation. | Lu, ZN., et al. 2021. Acta Pharmacol Sin. 42: 1808-1820. PMID: 34465912
- Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)-NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats. | Fawzy, MA., et al. 2021. Int J Mol Sci. 22: PMID: 34639009
- Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways. | Fawzy, MA., et al. 2022. Molecules. 27: PMID: 35209172
- Pantoprazole promotes the sensitivity of cervical cancer cells to cisplatin by inhibiting cisplatin-induced autophagy. | Su, G., et al. 2022. J Cancer Res Ther. 18: 362-369. PMID: 35645101
- Proton Pump Inhibitor Pantoprazole Modulates Intestinal Microbiota and Induces TLR4 Signaling and Fibrosis in Mouse Liver. | Assalin, HB., et al. 2022. Int J Mol Sci. 23: PMID: 36430244
Inhibitor of:
Ajuba, ATP4, ATP4A, Ces6, EG668210, Gastrin, Gastrokine 1, Gastrokine 3, GIF, H+/K+ ATPase β, HIAT1, KA2, NHE-11, NHE-9, Olfr951, Olfr957, Olr251, Pepsin A3, Pepsin C, Pepsinogen A, TCIRG1, and VacA.Activator of:
RESP18.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pantoprazole, 100 mg | sc-204830 | 100 mg | $87.00 | |||
Pantoprazole, 500 mg | sc-204830A | 500 mg | $250.00 |