Pannexin-2 Antibody (2B11): sc-517064
- Pannexin-2 Antibody (2B11) is a mouse monoclonal IgG1 κ Pannexin-2 antibody provided at 100 µg/ml
- raised against amino acids 133-219 representing partial length Pannexin-2 of human origin
- recommended for detection of Pannexin-2 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Pannexin-2 Antibody (2B11). This work is in progress.
QUICK LINKS
Pannexin-2 Antibody (2B11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pannexin-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Pannexin-2 antibody (2B11) is available as a non-conjugated format. Pannexin-2 plays a crucial role in cellular communication and is primarily located in the central nervous system, where Pannexin-2 contributes to forming heteromeric channels with Pannexin-1, facilitating ion and small molecule passage between cells. This function maintains homeostasis and coordinates responses to physiological stimuli in neural tissues. Pannexin-2 forms heteromeric channels rather than homomeric ones, highlighting unique structural properties and functional significance in gap junction communication. Conservation of Pannexin proteins across invertebrates and mammals underscores evolutionary importance in intercellular signaling. Research on Pannexin-2 can provide insights into various neurological conditions and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Pannexin-2 Antibody (2B11) References:
- Pannexins, a family of gap junction proteins expressed in brain. | Bruzzone, R., et al. 2003. Proc Natl Acad Sci U S A. 100: 13644-9. PMID: 14597722
- The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. | Baranova, A., et al. 2004. Genomics. 83: 706-16. PMID: 15028292
- Pannexin membrane channels are mechanosensitive conduits for ATP. | Bao, L., et al. 2004. FEBS Lett. 572: 65-8. PMID: 15304325
- Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. | Bruzzone, R., et al. 2005. J Neurochem. 92: 1033-43. PMID: 15715654
- Expression and functions of neuronal gap junctions. | Söhl, G., et al. 2005. Nat Rev Neurosci. 6: 191-200. PMID: 15738956
- Evolution of gap junction proteins--the pannexin alternative. | Panchin, YV. 2005. J Exp Biol. 208: 1415-9. PMID: 15802665
- Site-specific and developmental expression of pannexin1 in the mouse nervous system. | Ray, A., et al. 2005. Eur J Neurosci. 21: 3277-90. PMID: 16026466
- Pannexin1 and Pannexin2 expression in the developing and mature rat brain. | Vogt, A., et al. 2005. Brain Res Mol Brain Res. 141: 113-20. PMID: 16143426
- Cell-cell communication beyond connexins: the pannexin channels. | Barbe, MT., et al. 2006. Physiology (Bethesda). 21: 103-14. PMID: 16565476
- Pannexin 2 Localizes at ER-Mitochondria Contact Sites. | Le Vasseur, M., et al. 2019. Cancers (Basel). 11: PMID: 30862038
- Pannexin-2, a novel mitochondrial-associated membrane protein, may become the new strategy to treat and prevent neurological disorders. | Yang, Y., et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52: 1178-1180. PMID: 32770209
- Cryo-EM structure of human heptameric pannexin 2 channel. | Zhang, H., et al. 2023. Nat Commun. 14: 1118. PMID: 36869038
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pannexin-2 Antibody (2B11) | sc-517064 | 100 µg/ml | $316.00 |