Molecular structure of Pancuronium dibromide, CAS Number: 15500-66-0
Pancuronium dibromide (CAS 15500-66-0)
See product citations (2)
Alternate Names:
1,1′-(3α,17β-Dihydroxy-2β,5α-androstan-2β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide
Application:
Pancuronium dibromide is a nicotine neuromuscular antagonist
CAS Number:
15500-66-0
Purity:
≥98%
Molecular Weight:
732.68
Molecular Formula:
C35H60Br2N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Pancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuronium dibromide is a non-depolarizing agent.
Pancuronium dibromide (CAS 15500-66-0) References
- Open channel and competitive block of nicotinic receptors by pancuronium and atracurium. | Löwenick, CV., et al. 2001. Eur J Pharmacol. 413: 31-5. PMID: 11173060
- Evidence for a tonic GABA-ergic inhibition of excitatory respiratory-related afferents to presympathetic neurons in the rostral ventrolateral medulla. | Miyawaki, T., et al. 2002. Brain Res. 924: 56-62. PMID: 11743995
- Activation of mu-opioid receptors in rat ventrolateral medulla selectively blocks baroreceptor reflexes while activation of delta opioid receptors blocks somato-sympathetic reflexes. | Miyawaki, T., et al. 2002. Neuroscience. 109: 133-44. PMID: 11784705
- The detection and identification of quaternary nitrogen muscle relaxants in biological fluids and tissues by ion-trap LC-ESI-MS. | Kerskes, CH., et al. 2002. J Anal Toxicol. 26: 29-34. PMID: 11890177
- [Current place of neuroleptics in cardiac surgery under extracorporeal circulation. Cardiovascular effects of different combinations]. | Estanove, S., et al. 1976. Ann Anesthesiol Fr. 17: 1155-65. PMID: 14567
- Hypercapnia selectively attenuates the somato-sympathetic reflex. | Makeham, JM., et al. 2004. Respir Physiol Neurobiol. 140: 133-43. PMID: 15134661
- NK1 receptor activation in rat rostral ventrolateral medulla selectively attenuates somato-sympathetic reflex while antagonism attenuates sympathetic chemoreflex. | Makeham, JM., et al. 2005. Am J Physiol Regul Integr Comp Physiol. 288: R1707-15. PMID: 15731401
- In vivo imaging of seizure activity in a novel developmental seizure model. | Hewapathirane, DS., et al. 2008. Exp Neurol. 211: 480-8. PMID: 18402939
- Neuropeptide Y in the rostral ventrolateral medulla blocks somatosympathetic reflexes in anesthetized rats. | Kashihara, K., et al. 2008. Auton Neurosci. 142: 64-70. PMID: 18573695
- Multiplex Screening for Interacting Compounds in Paediatric Acute Myeloid Leukaemia. | Cairns, LV., et al. 2021. Int J Mol Sci. 22: PMID: 34576326
- Dosage adjustment for ceftazidime in patients with impaired renal function. | van Dalen, R., et al. 1986. Eur J Clin Pharmacol. 30: 597-605. PMID: 3530782
- Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. | Fryer, AD. and Maclagan, J. 1987. Naunyn Schmiedebergs Arch Pharmacol. 335: 367-71. PMID: 3600815
- Short-lasting, competitive neuromuscular blocking activity in a series of azobis-arylimidazo-(1,2-a)-pyridinium dihalides. | Bolger, L., et al. 1972. Nature. 238: 354-5. PMID: 4627710
- Extracellular pancuronium affects sodium current in chick embryo sensory neurones. | Maestrone, E., et al. 1994. Br J Pharmacol. 111: 283-7. PMID: 8012707
- Neurokinin-1 receptors and spinal cord control of blood pressure in spontaneously hypertensive rats. | Solomon, SG., et al. 1999. Brain Res. 815: 116-20. PMID: 9974130
Inhibitor of:
AChR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pancuronium dibromide, 10 mg | sc-203179 | 10 mg | $63.00 | |||
Pancuronium dibromide, 50 mg | sc-203179A | 50 mg | $218.00 | |||
Pancuronium dibromide, 100 mg | sc-203179B | 100 mg | $460.00 |