Pancuronium dibromide CAS: 15500-66-0
Pancuronium dibromide is a nicotine neuromuscular antagonist.

Pancuronium dibromide (CAS 15500-66-0)

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Alternate Names: 1,1′-(3α,17β-Dihydroxy-2β,5α-androstan-2β,16β-ylene) bis[1-methylpiperidinium] diacetate dibromide
Application: Pancuronium dibromide is a nicotine neuromuscular antagonist
CAS Number: 15500-66-0
Purity: ≥98%
Molecular Weight: 732.68
Molecular Formula: C35H60Br2N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Pancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuronium dibromide is a non-depolarizing agent.


References

1. Fryer, A.D., et al. 1987. Naunyn Schmiedebergs Arch Pharmacol. 335: 367-371. PMID: 3600815

2. Maestrone, E., et al. 1994. Br. J. Pharmacol. 111: 283-287. PMID: 8012707

3. Löwenick, C.V., et al. 2001. Eur. J. Pharmacol. 413: 31-35. PMID: 11173060

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM), ethanol (100 mg/ml at 25° C), and DMSO (100 mg/ml at 25° C).
Storage :
Store at room temperature
Melting Point :
215° C
IC50 :
Acetylcholine : IC50 = 5.5 ± 0.5 nM; Small conductance calcium-activated potassium channel: IC50 = 6.8 µM (rat); Plasmodium falciparum 3D7: IC50 = 10 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TN4930000
PubChem CID :
27350
Merck Index :
14: 7007
MDL Number :
MFCD00079223
EC Number :
239-532-5
Beilstein Registry :
4226892
SMILES :

Download SDS (MSDS)

Certificate of Analysis

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Pancuronium dibromide (CAS 15500-66-0)  Product Citations

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PMID: # 25269881  Lau, CG. et al. 2014. Mol. Reprod. Dev. 81: 994-1008.

Citations 1 to 1 of 1 total
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