PANC-1 Whole Cell Lysate: sc-364380

PANC-1 whole cell lysate is derived from the PANC-1 cell line, originally isolated from a human pancreatic carcinoma. This lysate is extensively used in research to study various cellular mechanisms related to cancer biology and signal transduction. PANC-1 cells are characterized by their aggressive growth and resistance to apoptosis, making them an ideal model for investigating the molecular pathways involved in tumorigenesis and metastasis. Researchers use PANC-1 whole cell lysate to analyze the activity of key signaling pathways, such as the PI3K/Akt/mTOR and MAPK/ERK pathways, which are critical for cell survival, proliferation, and migration. This lysate enables the study of protein expression levels, post-translational modifications, and the interactions between different signaling molecules. Additionally, it is used to investigate the effects of various chemical inhibitors and activators on these signaling pathways, providing insights into their roles in cancer progression. Recent studies have utilized PANC-1 whole cell lysate for proteomic and genomic analyses to identify novel biomarkers and targets associated with pancreatic cancer. By offering a detailed understanding of the cellular and molecular mechanisms underlying cancer biology, PANC-1 whole cell lysate remains a vital resource for advancing research in oncology and cell signaling.

PANC-1 Whole Cell Lysate References:

1. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility.  |  Nedjadi, T., et al. 2009. Br J Cancer. 101: 1145-54. PMID: 19724273
2. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.  |  Mancias, JD., et al. 2014. Nature. 509: 105-9. PMID: 24695223
3. Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction.  |  Jin, X., et al. 2017. Cancer Res. 77: 4328-4341. PMID: 28720574
4. FBP1 loss contributes to BET inhibitors resistance by undermining c-Myc expression in pancreatic ductal adenocarcinoma.  |  Wang, B., et al. 2018. J Exp Clin Cancer Res. 37: 224. PMID: 30201002
5. TRIM15 promotes the invasion and metastasis of pancreatic cancer cells by mediating APOA1 ubiquitination and degradation.  |  Sun, Y., et al. 2021. Biochim Biophys Acta Mol Basis Dis. 1867: 166213. PMID: 34311082
6. HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer.  |  Zhou, Y., et al. 2022. Theranostics. 12: 2080-2094. PMID: 35265200