Date published: 2025-9-26

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Panaxadiol (CAS 19666-76-3)

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Application:
Panaxadiol is which stimulates the growth and differentiation of bone marrow cells
CAS Number:
19666-76-3
Molecular Weight:
460.73
Molecular Formula:
C30H52O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Panaxadiol is a sapogenin derived from the roots of Panax species, commonly known as ginseng. In the field of scientific research, Panaxadiol is primarily studied for its unique biochemical properties and mechanisms of action at the cellular level, particularly in relation to cell signaling and metabolic regulation. One significant area of research involving Panaxadiol is its impact on cellular signaling pathways. The compound has been shown to influence pathways that regulate cell growth and survival. For instance, research indicates that Panaxadiol can modulate the activity of kinases involved in the mitogen-activated protein kinase (MAPK) pathways, which play critical roles in transmitting signals from cell surface receptors to the DNA in the nucleus. Moreover, Panaxadiol has been utilized in studies focusing on lipid metabolism. It is known to affect the expression of genes involved in lipid synthesis and breakdown, thus providing insights into cellular lipid management. This is achieved through its interaction with nuclear receptors and transcription factors that govern lipid metabolism genes. Panaxadiol′s ability to modulate these critical pathways offers a valuable tool for researchers studying the fundamental processes of cell signaling and metabolism. Its role in these basic biochemical pathways makes it a compound of interest beyond its traditional use, serving as a focal point for studies looking to explain the molecular underpinnings of cell function and regulation.


Panaxadiol (CAS 19666-76-3) References

  1. [Effect of panaxadiol saponin and panaxtrol saponin on proliferation of human bone marrow hemopoietic progenitor cells].  |  Niu, YP., et al. 2004. Zhongguo Zhong Xi Yi Jie He Za Zhi. 24: 127-9, 132. PMID: 15015445
  2. Panaxdiol Saponins Component Promotes Hematopoiesis and Modulates T Lymphocyte Dysregulation in Aplastic Anemia Model Mice.  |  Zheng, ZY., et al. 2019. Chin J Integr Med. 25: 902-910. PMID: 31802424
  3. 20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse.  |  Guo, WQ., et al. 2020. Evid Based Complement Alternat Med. 2020: 8747023. PMID: 32015754
  4. Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells.  |  Wang, Z., et al. 2020. Pharmacol Res. 155: 104727. PMID: 32113874
  5. In vivo pharmacokinetics, distribution, and excretion of an anticancer agent isolated from red ginseng, in rat.  |  Zheng, Q., et al. 2020. Xenobiotica. 50: 1323-1331. PMID: 32369406
  6. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway.  |  Jiang, S., et al. 2020. Eur J Pharmacol. 882: 173272. PMID: 32535096
  7. Amino acid, fatty acid, and carbohydrate metabolomic profiles with ginsenoside-induced insecticidal efficacy against Ostrinia furnacalis (Guenee).  |  Liu, S., et al. 2020. J Ginseng Res. 44: 544-551. PMID: 32617034
  8. Novel panaxadiol triazole derivatives induce apoptosis in HepG-2 cells through the mitochondrial pathway.  |  Xiao, S., et al. 2020. Bioorg Chem. 102: 104078. PMID: 32702511
  9. Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators.  |  Cheng, Y., et al. 2020. Bioorg Med Chem Lett. 30: 127364. PMID: 32738969
  10. Synthesis and evaluation of HIF-1α inhibitory activities of novel panaxadiol derivatives.  |  Wang, DY., et al. 2020. Bioorg Med Chem Lett. 30: 127652. PMID: 33130293

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Panaxadiol, 5 mg

sc-205791
5 mg
$102.00

Panaxadiol, 10 mg

sc-205791A
10 mg
$237.00