pan-TBC1D3 Antibody (C-8): sc-514028
- pan-TBC1D3 Antibody (C-8) is a mouse monoclonal IgG1 κ pan-TBC1D3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 502-528 near the C-terminus of TBC1D3C of human origin
- pan-TBC1D3 Antibody (C-8) is recommended for detection of a broad range of TBC1D3-related proteins of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-pan-TBC1D3 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for pan-TBC1D3 Antibody (C-8) for WB applications. These reagents are now offered in bundles with pan-TBC1D3 Antibody (C-8) (see ordering information below).
pan-TBC1D3 Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects pan-TBC1D3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-TBC1D3 antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBC1D3 protein plays a crucial role in cellular signaling as a GTPase-activating protein for Rab 5, which is essential for regulating endocytic trafficking and membrane dynamics. By facilitating the conversion of Rab 5 from its active GTP-bound state to its inactive GDP-bound form, TBC1D3 (C-8) monoclonal antibody helps maintain proper cellular function and homeostasis. Dysregulation of TBC1D3 and its family members, which include TBC1D3B, TBC1D3C, and TBC1D3G, has been implicated in various carcinomas, including prostate cancer, highlighting the importance of this protein in cancer biology. The genes encoding these proteins are located on human chromosome 17, a region that is significant for its association with key tumor suppressor genes such as p53 and BRCA1, both of which are critical for maintaining genomic stability and preventing tumorigenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
pan-TBC1D3 Antibody (C-8) References:
- PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. | Pei, L., et al. 2002. Cancer Res. 62: 5420-4. PMID: 12359748
- The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. | Masuda-Robens, JM., et al. 2003. Mol Cell Biol. 23: 2151-61. PMID: 12612085
- TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. | Hodzic, D., et al. 2006. Genomics. 88: 731-736. PMID: 16863688
- The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking. | Wainszelbaum, MJ., et al. 2008. J Biol Chem. 283: 13233-42. PMID: 18319245
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. | Ishibashi, K., et al. 2009. Genes Cells. 14: 41-52. PMID: 19077034
- Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes. | Onno, M., et al. 1993. Gene. 131: 209-15. PMID: 8406013
- Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes. | Onno, M., et al. 1993. DNA Cell Biol. 12: 107-18. PMID: 8471161
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pan-TBC1D3 Antibody (C-8) | sc-514028 | 200 µg/ml | $322.00 | |||
pan-TBC1D3 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-531008 | 200 µg Ab; 10 µg BP | $361.00 | |||
pan-TBC1D3 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-524579 | 200 µg Ab, 40 µg BP | $361.00 | |||
pan-TBC1D3 Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-544357 | 200 µg Ab; 20 µg BP | $361.00 | |||
pan-TBC1D3 Antibody (C-8) AC | sc-514028 AC | 500 µg/ml, 25% agarose | $424.00 | |||
pan-TBC1D3 Antibody (C-8) HRP | sc-514028 HRP | 200 µg/ml | $322.00 | |||
pan-TBC1D3 Antibody (C-8) FITC | sc-514028 FITC | 200 µg/ml | $336.00 | |||
pan-TBC1D3 Antibody (C-8) PE | sc-514028 PE | 200 µg/ml | $349.00 | |||
pan-TBC1D3 Antibody (C-8) Alexa Fluor® 488 | sc-514028 AF488 | 200 µg/ml | $364.00 | |||
pan-TBC1D3 Antibody (C-8) Alexa Fluor® 546 | sc-514028 AF546 | 200 µg/ml | $364.00 | |||
pan-TBC1D3 Antibody (C-8) Alexa Fluor® 594 | sc-514028 AF594 | 200 µg/ml | $364.00 | |||
pan-TBC1D3 Antibody (C-8) Alexa Fluor® 647 | sc-514028 AF647 | 200 µg/ml | $364.00 | |||
pan-TBC1D3 Antibody (C-8) Alexa Fluor® 680 | sc-514028 AF680 | 200 µg/ml | $364.00 | |||
pan-TBC1D3 Antibody (C-8) Alexa Fluor® 790 | sc-514028 AF790 | 200 µg/ml | $364.00 | |||
pan-TBC1D3 (C-8) Neutralizing Peptide | sc-514028 P | 100 µg/0.5 ml | $69.00 |