Anti-pan-TBC1D3 Antibody (C-8) is a mouse monoclonal IgG1 (kappa light chain) pan-TBC1D3 antibody provided at 200 µg/ml
specific for an epitope mapping between amino acids 502-528 near the C-terminus of TBC1D3C of human origin
Anti-pan-TBC1D3 Antibody (C-8) is recommended for detection of a broad range of TBC1D3-related proteins of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-pan-TBC1D3 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of pan-TBC1D3 (C-8): sc-514028.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for pan-TBC1D3 Antibody (C-8) for WB applications. These reagents are now offered in bundles with pan-TBC1D3 Antibody (C-8) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
pan-TBC1D3 Antibody (C-8) is a high quality monoclonal pan-TBC1D3 antibody (also designated pan-TBC1D3 antibody) suitable for the detection of the pan-TBC1D3 protein of mouse, rat and human origin. pan-TBC1D3 Antibody (C-8) is available as both the non-conjugated anti-pan-TBC1D3 antibody form, as well as multiple conjugated forms of anti-pan-TBC1D3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The TBC1D3 proteins, some of which include TBC1D3, TBC1D3B, TBC1D3C and TBC1D3G, contain Rab-GAP TBC domains and are thought to function as GTPase activating proteins for Rab 5, thereby mediating Rab 5 function throughout the cell. TBC1D3 family members exhibit different expression patterns and may be involved in the pathogenesis of a variety of carcinomas, including prostate cancer. The genes encoding TBC1D3, TBC1D3B, TBC1D3C and TBC1D3G map to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences