pan MRGX Antibody (F-1): sc-393652

pan MRGX Antibody (F-1) is a mouse monoclonal IgM kappa antibody that detects pan MRGX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). pan MRGX (F-1) antibody is available as the non-conjugated form. The Mas-related G protein-coupled receptor member X1 (MRGX) plays a crucial role in the sensory nervous system, particularly in nociceptive neurons, which are responsible for the perception of pain. This integral membrane protein is not only essential for the modulation of pain but also influences the development of nociceptors, thereby impacting pain sensitivity and response. The MRGX family consists of four members (MRGX1-4), with MRGX1 and MRGX2 receptors activating both Gα q- and Gα i-regulated pathways, while MRGX3 and MRGX4 primarily engage Gα q-regulated pathways. The activation of Gα q proteins is vital as it triggers calcium signaling, a key process in neuronal communication and pain signaling. Notably, MRGX receptors are uniquely expressed in a specific subset of small dorsal root and trigeminal sensory neurons, highlighting their specialized function in pain pathways and making them significant targets for research into pain modulation and sensory neuron development.

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pan MRGX Antibody (F-1) References:

1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.  |  Dong, X., et al. 2001. Cell. 106: 619-32. PMID: 11551509
2. Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.  |  Lembo, PM., et al. 2002. Nat Neurosci. 5: 201-9. PMID: 11850634
3. Identification of G protein-coupled receptor genes from the human genome sequence.  |  Takeda, S., et al. 2002. FEBS Lett. 520: 97-101. PMID: 12044878
4. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.  |  Han, SK., et al. 2002. Proc Natl Acad Sci U S A. 99: 14740-5. PMID: 12397184
5. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.  |  Robas, N., et al. 2003. J Biol Chem. 278: 44400-4. PMID: 12915402
6. Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.  |  Chen, H. and Ikeda, SR. 2004. J Neurosci. 24: 5044-53. PMID: 15163697
7. Cloning and expression of MRG receptors in macaque, mouse, and human.  |  Zhang, L., et al. 2005. Brain Res Mol Brain Res. 133: 187-97. PMID: 15710235
8. Proadrenomedullin N-terminal peptide and cortistatin activation of MrgX2 receptor is based on a common structural motif.  |  Nothacker, HP., et al. 2005. Eur J Pharmacol. 519: 191-3. PMID: 16111673
9. Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors.  |  Burstein, ES., et al. 2006. Br J Pharmacol. 147: 73-82. PMID: 16284629

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-pan MRGX Antibody (F-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-pan MRGX Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

pan MRGX Antibody (F-1) Specifications

Alternate Product Name: pan MRGX

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 114-135

Epitope Target: MRGX1

Epitope Species: human

Product Reactivity/Detection: MRGX1, MRGX2, MRGX3 and MRGX4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for pan MRGX Antibody (F-1): P: Blocking Peptide