pan GnRH Antibody (302): sc-66044

pan GnRH Antibody (302) is a mouse monoclonal IgG1 antibody that detects gonadotropin-releasing hormone (GnRH) in human samples through western blotting (WB). anti-GnRH antibody (302) plays a crucial role in studying the hypothalamic-pituitary-gonadal axis, which is essential for regulating human reproduction. GnRH, a decapeptide produced by hypothalamic neurons, is secreted in a pulsatile manner into the capillary plexus of the median eminence, influencing the release of luteinizing hormone and follicle-stimulating hormone from gonadotropic cells in the anterior pituitary. Notably, GnRH is expressed not only in the anterior pituitary tissue but also in the acrosomal region of human sperm and various cancer cells, highlighting its significance in both reproductive biology and oncology. The binding of GnRH to its specific G protein-coupled receptor in the pituitary is vital for the regulation of gonadotropin synthesis and secretion, making GnRH a key player in fertility and hormonal balance. GnRH monoclonal antibody (302) provides accurate detection of GnRH, proving invaluable for researchers investigating its role in these critical physiological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

pan GnRH Antibody (302) References:

1. Effect of stress on the expression of GnRH and GnRH receptor (GnRH-R) genes in the preoptic area-hypothalamus and GnRH-R gene in the stalk/median eminence and anterior pituitary gland in ewes during follicular phase of the estrous cycle.  |  Ciechanowska, M., et al. 2007. Acta Neurobiol Exp (Wars). 67: 1-12. PMID: 17474316
2. Expression of the GnRH and GnRH receptor (GnRH-R) genes in the hypothalamus and of the GnRH-R gene in the anterior pituitary gland of anestrous and luteal phase ewes.  |  Ciechanowska, M., et al. 2008. Anim Reprod Sci. 108: 345-55. PMID: 17945441
3. The central effect of beta-endorphin and naloxone on the expression of GnRH Gene and GnRH receptor (GnRH-R) gene in the hypothalamus, and on GnRH-R gene in the anterior pituitary gland in follicular phase ewes.  |  Ciechanowska, MO., et al. 2008. Exp Clin Endocrinol Diabetes. 116: 40-6. PMID: 17973212
4. Effects of GABA(A) receptor modulation on the expression of GnRH gene and GnRH receptor (GnRH-R) gene in the hypothalamus and GnRH-R gene in the anterior pituitary gland of follicular-phase ewes.  |  Ciechanowska, M., et al. 2009. Anim Reprod Sci. 111: 235-48. PMID: 18434046
5. Neuroendocrine regulation of GnRH release and expression of GnRH and GnRH receptor genes in the hypothalamus-pituitary unit in different physiological states.  |  Ciechanowska, M., et al. 2010. Reprod Biol. 10: 85-124. PMID: 20668503
6. Trichostatin A reduces GnRH mRNA expression with a concomitant increase in retinaldehyde dehydrogenase in GnRH-producing neurons.  |  Kanasaki, H., et al. 2015. Mol Cell Endocrinol. 413: 113-9. PMID: 26116234
7. Possible roles of gonadotropin-releasing hormone (GnRH) and melatonin in the control of gonadal development of clam Ruditapes philippinarum.  |  Ding, M., et al. 2021. Comp Biochem Physiol A Mol Integr Physiol. 262: 111059. PMID: 34455085
8. Single-Dose Versus Multiple-Dose GnRH Agonist for Luteal-Phase Support in Women Undergoing IVF/ICSI Cycles: A Network Meta-Analysis of Randomized Controlled Trials.  |  Liu, Y., et al. 2022. Front Endocrinol (Lausanne). 13: 802688. PMID: 35432219
9. Ovulation triggering with hCG alone, GnRH agonist alone or in combination? A randomized controlled trial in advanced-age women undergoing IVF/ICSI cycles.  |  Zhou, C., et al. 2022. Hum Reprod. 37: 1795-1805. PMID: 35595223
10. Transcriptomic response to GnRH down regulation by RNA interference in clam Ruditapes philippinarum, suggest possible role in reproductive function.  |  Jiang, S., et al. 2023. Comp Biochem Physiol A Mol Integr Physiol. 277: 111367. PMID: 36608928

The preferred GnRH I antibody is GnRH I Antibody (HU11B): sc-32292.